ZHANG Ruiping
Dr. Zhang engaged in the research of new methods of mass spectrometry and its application in biomedical analysis. She has undertaken and participated in more than 20 national scientific research projects. Published more than 60 SCI papers, and applied for 4 patents. Dr. Zhang has developed advanced mass spectrometry imaging technology and multi-functional liquid chromatography-mass spectrometry (HPLC-MS) method, aiming to obtain new understanding of metabolic network and its regulation rules. The current research work is divided into the following aspects.
1) Metabonomics technology development, including cell metabonomics, spatial resolved metabolic flux, in situ derivatization mass spectrometry imaging.
2) Discovery and verification of functional metabolites.
3) Evaluation of early efficacy and toxicity of drugs.
4) Metabolic basis of sex-related diseases.
1. Rewiring of purine metabolism in response to acidosis stress in glioma stem cells. Cell Death Dis. , 2021, 12: 277.
2. Spatially resolved metabolomics combined with multicellular tumor spheroids to discover cancer tissue relevant metabolic signatures. Anal. Chim. Acta , 2021, 1155: 338342.
3. The impact of chronic environmental metal and benzene exposure on human urinary metabolome among Chinese children and the elderly population. Ecotoxicol. Environ. Saf. , 2019, 169: 232-239.
4. Systematic optimization and evaluation of sample pretreatment methods for LC-MS-based metabolomics analysis of adherent mammalian cancer cells. Anal Methods , 2019, 11: 3014-3022.
5. Combination of Droplet Extraction and Pico-ESI-MS Allows the Identification of Metabolites from Single Cancer Cells. Anal Chem , 2018, 90(16): 9897-9903.
6. LC-MS-based metabolomics reveals metabolic signatures related to glioma stem-like cell selfrenewal and differentiation. RSC Advances , 2017, 7: 24221–24232.
7. Human Metabolic Responses to Chronic Environmental Polycyclic Aromatic Hydrocarbon Exposure by a Metabolomic Approach. Journal of Proteome Research , 2015, 14: 2583–2593.
8. A rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of S-phenylmercapturic acid in human urine. Anal Methods , 2013, 5: 6081–6085.
9. Analysis of multiplex endogenous estrogen metabolites in human urine using ultra-fast liquid chromatography-tandem mass spectrometry: A case study for breast cancer. Anal Chim Acta , 2012, 711: 60–68.
10. Integrated rapid resolution liquid chromatography-tandem mass spectrometric approach for screening and identification of metabolites of the potential anticancer agent 3,6,7-trimethoxyphenanthroindolizidine in rat urine. Anal Chim Acta , 2012, 731: 60–67.
1. 2014, CAIA Science and Technology Award, First Award, China Association for Instrumental Analysis (CAIA), China.
2. 2011, The Chinese Medical Science and Technology Award, Third Prize, Chinese Medical Association, China.
3. 2010, Beijing science and technology award, Second Prize, Beijing Municipal Science & Technology Commission, China.
