ZHANG Li
Education
1999 – 2003: Hebei University of Technology, Bachelor of Pharmacy Engineering
2003 – 2008: Chinese Academy of Medical Sciences & Peking Union Medical College, Doctor of Pharmaceutical Analysis
Work experience
2008 – Present: Institute of Materia Medica, CAMS & PUMC
Research area
Studies of polymorphism and co-crystals of APIs, including: polymorphic screening, characterization analysis, druggability evaluation and polymorphic quality control of innovative drugs and lead compounds.
Zhang Li has presided over and undertaken 4 projects and participated in a number of national projects with total number of projects exceeding 20. More than 40 scientific papers and 5 monographs have been published. More than 40 invention patents have been applied for, 24 of which have been authorized.
1. The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro. Biochemical Pharmacology, 2021.
2. Theoretical calculation and structural analysis of the cocrystals of three flavonols with praziquantel. Cryst. Growth Des., 2021.
3. Progress in research on artificial intelligence applied to polymorphism and cocrystal prediction. ACS Omega. 2021.
4. Crystal structure of 4-amino-N-(2-pyrimidinyl) benzenesulfonamide–1,4-dioxane (1/1), C14H18N4O4S. Zeitschrift für Kristallographie. 2021
5. Characterization of a new solvatomorph of drospirenone by thermogravimetry-mass spectrometry combined with other solid-state analysis methods. ACS Omega. 2020.
6. A Novel Co-crystal of bexarotene and ligustrazine improves pharmacokinetics and tissue distribution of bexarotene in SD rats. Pharmaceutics, 2020.
7. Analysis of four solvatomorphs of betulin by TG-DTA-EI/PI-MS system equipped with the skimmer-type interface. Nat. Prod. Bioprospect. 2020.
8. Structural features and interactions of new sulfamethazine salt and cocrystal. Journal of Molecular Structure, 2020.
9. Structural and computational insights into cocrystal interactions: a case on cocrystals of antipyrine and aminophenazone. Cryst. Growth Des. 2019.
10. Structural and computational study of four new solvatomorphs of betulin: A combined X-ray, Hirshfeld surface, and thermal analysis. Journal of Pharmaceutical Sciences, 2017.
11. Salt screening and characterization of ciprofloxacin. Acta crystallographica section b, 2016.
12. Isostructurality Among 5 Solvatomorphs of Betulin: X-RayStructure and Characterization. Journal of Pharmaceutical Sciences, 2016.
1. Polymorphic Drugs 2019 (2nd Edition). Lu, Y., Du, G.H, Yang, S.Y. etc. Edited by Cheng Y. People's Medical Publishing House , Pages208-221,270-282,373-412. Print ISBN: 978-7-117-28034-1.
2. Polymorphic Drugs 2009 (1st Edition). Lu, Y., and Du, G.H, Yang, S.Y. etc. Edited by Gao B. and Kuang L.J. People's Medical Publishing House , Pages 69-107. Print ISBN: 978-7-117-11571-1.
3. Natural Small Molecule Drugs from Plants. Du, G.H., Fang L.H., Lu, Y., Chen N.H., Wang J.H., Qin X.M, Zhang, L etc.. Edited by Cao J.H. People's Medical Publishing House, Pages 226-228. Print ISBN: 978-7-117-24870-9.
4. Natural Small Molecule Drugs from Plants. Du, G.H., Fang L.H., Lu, Y., Chen N.H., Wang J.H., Qin X.M, Zhang, L etc. People's Medical Publishing House, Pages 226-228. Print ISBN: 978-7-117-29101-9.
1. 2016, State Scientific & Technological Progress Award, Second Prize, China.
2. 2014, Beijing Scientific & Technological Progress Award, First Prize, Beijing, China.
