ZHANG Leilei
Education background
09/2005-07/2008: The Institute of Materia Medica, CAMS & PUMC, Medicinal Chemistry, Ph.D.
09/2001-07/2004: Shandong Academy of Medical Sciences, Natural Medicinal Chemistry, Master
09/1997-07/2001: Shandong University, Pharmaceutical Sciences, Bachelor
Work experience
10/2017 – present: Institute of Materia Medica, CAMS & PUMC, associate professor
09/2008 – 09/2017: Institute of Materia Medica, CAMS & PUMC, assistant professor
09/2004 – 07/2005: Shandong Academy of medical Sciences, assistant researcher
1. A single component self-assembled thermally activated delayed fluorescence nanoprobe. Chemical Communications, 2020，56(17): 2550-2553.
2. Gadolinium-labeled aminoglycoside and its potential application as a bacteria-targeting magnetic resonance imaging contrast agent. Analytical Chemistry, 2018，90(3): 1934-1940.
3. A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging. Acta Pharmaceutica Sinica B, 2018, 8(3): 401-408.
4.Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays. Journal of Medicinal Chemistry, 2009, 52, 4419-4428.
5.Identification of 3, 5, 6-substituted indolin-2-one's inhibitors of aurora B by development of a luminescent kinase assay. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 2937-2942.
6. Simultaneous quantification of six major triterpenoid saponins in Schefflera kwangsiensis using high-performance liquid chromatography coupled to orbitrap mass spectrometry. Natural product research, 2015，29, 1350-1357.
7. Design, synthesis and evaluation of novel derivatives of Orotic acid amide as potent glucokinase activators. Letters in Drug Design & Discovery, 2017， 14, 252- 261.
8. The stereoselective C-alkylation of chiral nitronic acid (4S*, 5R) -(+)-4-(6-nitro-6-carbethoxymethyl)-5-[(1R)-menthyloxy]-3,4-dihydro-2(5H)-furanone. J. Indian Chem. Soc., 2014，91, 1335-1339.
