ZHANG Jianjun
Principal Investigator
Work experience
08/1999—present Professor (2004--), Associate Professor in Department of Pharmacology, Institute of Materia Medica, CAMS
06/1998—06/1999 Postdoctoral fellow in Department of Neurology, UCLA
11/1996—05/1998 Postdoctoral fellow in Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center in Shereveport
07/1995—10/1996 Assistant Scientist in Max-Planck-Institute For Experimental Medicine, Gottingen, Germany
07/1991—06/1995 Assistant Professor in Department of Pharmacology, Institute of Materia Medica, CAMS
Education
1988-1991: Chinese Academy of Medical Sciences /Peking Union Medical College, Master of Medicine;
1983-1988: School of Pharmacy, Beijing Medical University, B.Sc.
Research interests
Zhang Jianjun is mainly engaged in the research on the pathogenesis of neuropsychiatric diseases and the discovery and development of therapeutic drugs. Her research directions include:
1. Stress-related diseases such as depression/gastric ulcer.
2. Neurodegenerative diseases such as AD, PD, multiple sclerosis.
1. DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage. Eur J Pharmacol. 2020.
2. Neuroprotective effects of compound FLZ in an ischemic model mediated by improving cerebral blood flow and enhancing Hsp27 expression. Brain Research. 2016.
3. N(6)-(3-methoxyl-4-hydroxybenzyl) adenine riboside induces sedative and hypnotic effects via GAD enzyme activation in mice. Pharmacol Biochem Behav. 2014.
4. Sedative and hypnotic activity of N(6)-(3-methoxyl-4-hydroxybenzyl) adenine riboside (B2), an adenosine analog. Pharmacol Biochem Behav. 2014.
5. Microbial transformations of buagarofuran, an anti-anxietic agent. Tetrahedron，2014
6. Herbal insomnia medications that target GABAergic systems: a review of the psychopharmacological evidence. Curr Neuropharmacol. 2014.
7. Anticonvulsant activity of B2, an adenosine analog, on chemical convulsant-induced seizures. PLoS One. 2013.
8. Sedative–hypnotic effect of YZG-330 and its effect on chloride influx in mouse brain cortical cells. Acta Pharmaceutica Sinica B. 2013.
9. NHBA isolated from Gastrodia elata exerts sedative and hypnotic effects in sodium pentobarbital-treated mice. Pharmacol Biochem Behav. 2012.
10. A natural squamosamide derivative FLZ inhibits homocysteine- induced rat brain microvascular endothelial cells dysfunction. Biochemical and Biophysical Research Communications. 2012.
11. Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. Eur J Pharmacol. 2012.
12. The Antidepressant effect of Cynanchum auriculatum in mice. Pharm Biol. 2012.
13. Reduced brain-derived neurotrophic factor expression in cortex and hippocampus involved in the learning and memory deficit in molarless SAMP8 mice. Chin Med J. 2011.
14. Protective effects of extract of Coeloglossum viride var. bracteatum on ischemia-induced neuronal death and cognitive impairment in rats. Behavioural Pharmacology. 2008.
15. The novel squamosamide derivative FLZ protects against 6-hydroxydopamine-induced apoptosis through inhibition of related signal transduction in SH-SY5Y cells. Eur J Pharmacol. 2007.
16. The novel squamosamide derivative (compound FLZ) attenuated 1-methyl,4-phenyl-pyridinium ion (MPP+)-induced apoptosis and alternations of related signal transduction in SH-SY5Y cells. Neuropharmacology. 2007.
17. Dactylorhin B reduces toxic effects of beta-amyloid fragment (25-35) on neuron cells and isolated rat brain mitochondria. Naunyn Schmiedebergs Arch Pharmacol. 2006.
18. Ninmodipine treatment to assess a modified mouse model of intracerebral hemorrhage. Brain Research，2006.
19. Effects of Coeloglossum. viride var. bracteatum extract on memory deficits and pathological changes in senescent mice. Basic & Clinical Pharmacology & Toxicology，2006.
20. Coeloglossum viride var. bracteatum extract attenuates D-galactose and NaNO2 induced memory impairment in mice. J Ethnopharmacol. 2006.
21. Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice. Liver Int. 2005.
22. Effects of novel anxiolytic 4-butyl-alpha-agarofuran on levels of monoamine neurotransmitters in rats. Eur J Pharmacol. 2004.
23. Peripheral interleukin-6 administration increases extracellular concentrationsof serotonin and the evoked release of serotonin in the rat striatum. Neurochem Int. 2001.
