ZHANG Dongming
Principal Investigator
Zhang Dongming is a professor, doctoral supervisor at the Department of Natural Medicinal Chemistry. His main research interests are the discovery of active ingredients in Chinese herbal medicine and the development of new drugs. More than 500 new compounds were isolated from more than 20 kinds of Chinese herbal medicine. Among them, 5 novel framework compounds were selected as hot molecules by the international well-known journal Nat. Prod. Rep. Two drug candidates for chronic kidney disease, cerebral ischemia and Alzheimer's disease are in development. He has published more than 100 papers as corresponding author in high-level academic journals such as Org. Lett., Europ. J. Med. Chem., J. Nat. Prod., Bioorganic Chemistry, and Chinese Chemical Letters. More than 80 papers have been included in SCI and 14 patents have been granted.
1. Psiguamers A–C, three cytotoxic meroterpenoids bearing a methylated benzoylphloroglucinol framework from Psidium guajava and total synthesis of 1 and 2. Chinese Chemical Letters, 2021, 32: 1721-1725.
2. Bioactive monoterpene phenol dimers from the fruits of Psoralea corylifolia L. Bioorganic Chemistry, 2021, 112: 104924-104935.
3. Guajamers A-I, rearranged polycyclic phloroglucinol meroterpenoids from Psidium guajava leaves and their antibacterial activity. Chinese Journal of Chemistry, 2021, 39: 1129-1137.
4. Three unprecedented biphenyl derivatives bearing C6-C3 carbon skeleton from the bark of Magnolia offificinalis var. Biloba. Chinese Chemical Letters , 2020, 31: 1248–1250.
5. Novel nitric oxide-releasing derivatives of triptolide as antitumor and anti-inflammatory agents: Design, synthesis, biological. Europ. J. Med. Chem, 2020, 190: 112079-112086.
6. Bioactive flavonoid dimers from Chinese dragon's blood, the red resin of Dracaena cochinchinensis. Bioorganic Chemistry, 2020, 97: 103659-103667.
7. The isolation, absolute configuration and activities of 18(4 → 3)-abeo-abietane lactones from Tripterygium wilfordii. Bioorganic Chemistry, 2019, 82: 68-73.
8. New dammarane-type saponins from the leaves of Panax notoginseng. Chinese Chemical Letters , 2019, 30: 447–450.
9. Nototronesides A–C, three triterpene saponins with a 6/6/9 fused tricyclic tetranordammarane carbon skeleton from the leaves of Panax notoginseng. Org. Lett, 2018, 20 (15): 4549-4553.
10. Magterpenoids A-C, three polycyclic meroterpenoids with PTP1B inhibitory activity from the bark of Magnolia officinalis var. Biloba. Org. Lett , 2018, 20 (12): 3682-3686.
11. Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo. Europ. J. Med. Chem, 2018, 143 (1): 438-448.
12. Neuroprotective dihydroagarofuran sesquiterpene derivatives from the leaves of Tripterygium wilfordii. J. Nat. Prod, 2018, 81 (2): 270-278.
13. Guajavadimer A, a dimeric caryophyllene-derived meroterpenoid with a new carbon skeleton from the leaves of Psidium guajava. Org. Lett , 2016, 18 (2): 168-171.
Phenolic acid chemistry. Edited by Zhang Dongming. Chemical Industry Press, Print ISBN: 978-7-122-03736-7.
1. 2014, the second prize of the State Scientific and Technological Progress Award, China.
2. 2013, the first prize of Beijing Science and Technology Progress Award, China.
