ZHANG Dongfeng
Education
2005-2010: Ph.D. in Medicinal Chemistry, Peking Union Medical College
1999-2003: B.S. in Pharmaceutical Engineering, Shenyang Pharmaceutical University
RESEARCH INTERESTS
1. Medicinal chemistry: structure-based molecular design.
1) Discovery of new antibiotics targeting Mycobacterium tuberculosis and Gram-positive bacteria.
2) Development of tyrosine kinase inhibitors as antitumor agents.
2. Development of new organic methodology.
1. A mild and metal-free synthesis of chiral 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazines. Tetrahedron , 2021, 10.1016/j.tet.2021.132304.
2. Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads. Bioorganic Chemistry , 2021, 114, 105110.
3. Discovery of a candidate containing an ( S )3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro1 H inden scaffold as a highly potent Pan-inhibitor of the BCR-ABL kinase including the T315I resistant mutant for the treatment of chronic myeloid leukemia. Journal of Medicinal Chemistry , 2021, 64(11), 7434−7452.
4. Identification of novel tricyclic benzo[1,3]oxazinyloxazolidinones as potent antibacterial agents with excellent pharmacokinetic profiles against drug-resistant pathogens. Journal of Medicinal Chemistry , 2021, 64(6), 3234−3248.
5. Discovery of a conformationally constrained oxazolidinone with improved safety and efficacy profiles for the treatment of multidrug-resistant tuberculosis. Journal of Medicinal Chemistry , 2020, 63(17), 9316-9339.
6. Efficient and stereoselective one-pot synthesis of benzo[ b ]oxazolo[3,4- d ][1,4]oxazin-1-ones. RSC Advances , 2020, 10, 24037-24044.
7. Design, synthesis, and biological evaluation of novel 4 H -chromen-4-one derivatives as antituberculosis agents against multidrug-resistant tuberculosis. European Journal of Medicinal Chemistry , 2020, 189, 112075.
8. A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide. Synthetic Communications , 2020, 50(6), 813-822 9.
9. An efficient synthesis of Aryl-substituted pyrroles by the Suzuki–Miyaura coupling reaction of SEM-protected pyrroles. Molecules, 2019, 24(8), 1594.
10. Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold. Bioorganic Chemistry , 2019, 85, 229-239.
11. An efficient and facile access to highly functionalized pyrrole derivatives. Beilstein Journal of Organic Chemistry, 2018, 14, 884-890.
12. Discovery of fluorine-containing benzoxazinyl-oxazolidinones for the treatment of multidrug resistant tuberculosis. ACS Medicinal Chemistry Letters , 2017, 8 (5), 533-537.
13. An improved synthesis of (1 S ,4 S )-2-oxa-5-azabicyclo[2.2.1]heptane. Chinese Chemical Letters , 2014, 45(3), 479-481.
14. An efficient and convenient protocol for synthesis of 1,1-difluoro-6-nitro-2,3-dihydro-1 H -indene derivatives. Synthesis , 2014, 46(5), 613-620.
15. Synthesis and biological evaluation of novel 2-methoxypyridylamino-substituted riminophenazine derivatives as antituberculosis agents. Molecules , 2014, 19(4), 4380-4394.
16. Identification of less lipophilic riminophenazine derivatives for the treatment of drug-resistant tuberculosis. Journal of Medicinal Chemistry , 2012, 55(19), 8409-8417.
