ZHANG Dan
Principal Investigator
Education background
07/2001-08/2006 Ph.D., Major in Neuropharmacology, Institute of Materia Medica, CAMS & PUMC
07/1996-07/2001 B.S., Major in Pharmacology, Peking University Health Science Center, Beijing, P. R. China
Professional and research experience
09/2016- present Professor, Department of Pharmacology, Institute of Materia Medica, CAMS & PUMC
08/2010-09/2016 Associate Professor, Department of Pharmacology, Institute of Materia Medica, CAMS & PUMC
08/2006-08/2010 Postdoctoral Fellow, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, NIH, USA
Research interests
1. Explore the pathogenesis, new targets and new drug development of neuropsychiatric diseases;
2. Research on the mechanisms of inflammation and immunity-related diseases and develop therapeutic drugs;
3. Research on the biological target and effect of active natural products;
4. Study on the mechanisms of gut microbes in the process of various diseases and develop therapeutic drugs.
1. Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson's disease treatment. Acta Pharmaceutica Sinica B. Accepted.
2. Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-kB pathway through microbiot-gut-brain axis. Acta Pharmaceutica Sinica B, 2021.
3. Autoimmune polyendocrine syndrome induced by immune checkpoint inhibitors: a systematic review. Cancer Immunol Immunother, 2020.
4. Novel phloroglucinol derivative Compound 21 protects experimental autoimmune encephalomyelitis rats via inhibiting Th1/Th17 cell infiltration. Brain Behav Immun, 2020.
5. GJ-4 alleviates Aβ25-35-induced memory dysfunction in mice through protecting the neurovascular unit. Biomed Pharmacother, 2020.
6. Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model. Redox Biol, 2019.
7. Discovery of coumarinMannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease. European journal of medicinal chemistry, 2019.
8. Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation. Sci China Life Sci, 2019.
9. Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway. Redox Biol, 2018.
10. NADPH oxidase-derived H2O2 mediates the regulatory effects of microglia on astrogliosis in experimental models of Parkinson's disease. Redox Biol, 2017.
1. Practical Molecular Pharmacology. Wang Xiaoliang. Peking union medical college press . Print ISBN: 9787567904118.
2. The New Techniques and Methods in Pharmacological Research. Chen Xiaoguang. Peking union medical college press . Print ISBN: 9787811368758.
3. The New Targets and Ideas in Pharmacological Research. Chen Xiaoguang. Peking union medical college press . Print ISBN: 9787811367348.
