YUAN Tianyi
Education and work background
2018-present: Associate professor, Institute of Materia Medica, CAMS & PUMC, Beijing, China
2015-2018: Assistant professor, Institute of Materia Medica, CAMS & PUMC, Beijing, China
2010-2015: Ph.D., Pharmacology, Peking Union Medical College, Tsinghua University, Beijing, China
2006-2010: Bachelor, Pharmaceutical Science, China Pharmaceutical University,
Research area
1. Developing high through-put screening models and new drugs related to cardiovascular diseases
2. In vivo drug efficacy study on hypertension crisis, pulmonary hypertension, ischemic heart disease, and other vascular diseases.
3. In vitro drug efficacy study on isolated organs including heart, large vessels and small arteries.
4. Novel therapeutic target discovery concerning vascular remodeling and target validation.
1. Puerarin protects pulmonary arteries from hypoxic injury through the BMPRII and PPARγ signaling pathways in endothelial cells. Pharmacological Reports, 2019; 71(5):855-861.
2. A novel hypertensive crisis rat model established by excessive norepinephrine infusion and the potential therapeutic effects of Rho-kinase inhibitors on it. Biomedicine & Pharmacotherapy. 2019; 109: 1867-1875.
3. Vasorelaxant effect of quercetin on cerebral basilar artery in vitro and the underlying mechanisms study. Journal of Asian Natural Products Research. 2018; 20(5):477-487.
4. Salvianolic acid A, a component of Salvia Miltiorrhiza Bunge, attenuates endothelial-mesenchymal transition of HPAECs induced by hypoxia. American Journal of Chinese Medicine, 2017; 45(6):1185-1200.
5. The protective effect of DL0805 derivatives on pulmonary artery cells and the underlying mechanisms study. Current Vascular Pharmacology, 2017; 15(5): 469-76.
Natural Small Molecule Drugs from Plants, Du Guan-hua. Springer Press , Pages 313-318, 679-684. ISBN：978-981-10-8021-0.
