YANG Yanfang
Yang Yanfang has a dual professional background of polymer science and pharmaceutics and her research interests focus on new drug delivery system, design of new intelligent delivery carrier materials, gene delivery, tumor targeted delivery system, taste-masking technologies of paediatric formulations, research of intelligent drug delivery carrier based on tumor immune microenvironment and so on. She has conducted and participated in a number of national, provincial and ministerial-level scientific research projects. She has also participated in the completion of a number of new drug R&D projects. Among them, as the project leader, Yang has presided over a number of research projects. As a result of these studies, many academic papers have been published in academic journals, including top journals in pharmaceutics such as Biomaterials, Journal of Controlled Release, Bioactive Materials, etc..
1. PEGylated liposomes with NGR ligand and heat-activable cell penetrating peptide-doxorubicin conjugate for tumor-specific therapy. Biomaterials , 2014, 35(14): 4368-4381.
2. Sequential delivery of VEGF siRNA and paclitaxel for PVN destruction, antiangiogenesis, and tumor cell apoptosis procedurally via a multi-functional polymer micelle. Journal of Controlled release , 2018, 287: 103-120.
3. Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma. Bioactive Materials , 2020, 5: 694-708.
4. Construction of chlorogenic acid-containing liposomes with prolonged antitumor immunity based on T cell regulation. Science China life science , 2020, DOI: 10.1007/s11427-020-1739-6.
5. Dual stimulus of hyperthermia and intracellular redox environment triggered release of siRNA for tumor-specific therapy. International Journal of Pharmaceutics , 2016, 506: 158-173.
6. Acid Sensitive Polymeric Micelles Combining Folate and Bioreducible Conjugate for Specific Intracellular siRNA Delivery. Macromolecular Bioscience , 2016, 16: 759-773.
7. Folate and CPP mediated specific delivery of camptothecin to tumor via pH and reduction dual-sensitive micelles. Journal of Controlled release , 2017, 259: e164-e165.
8. Thermal and magnetic dual-responsive liposomes with a cell-penetrating peptide-siRNA conjugate for enhanced and targeted cancer therapy. Colloids and Surfaces B: Biointerfaces , 2016, 146: 607-615.
9. Photo-Responsive and NGR-Mediated Multifunctional Nanostructured Lipid Carrier for Tumor-Specific Therapy. Journal of Pharmaceutical Sciences , 2015, 104: 1328-1339.
10. Photolabile-caged peptide-conjugated liposomes for siRNA delivery. Journal of Drug Targeting , 2015, 23: 789-799.
11. Polymers Used as Flavor-masking Agents for Bitter Substances in Oral Administration Preparations. China Pharmacist ，2021, 24(1):132-138.
12. Co-culture of human breast adenocarcinoma cells and human umbilical vein endothelial cells to mimic in vivo tumor microenvironment. Acta Pharmaceutica Sinica , 2018, 53: 403-409.
13. Establishement of the content Determination Method for Chlorogenic Acid in PEGylated Liposomes. China Pharmacist ，2019, 22(3): 429-433.
14. A review on the influences of size and surface charge of liposome on its targeted drug delivery in vivo. Acta Pharmaceutica Sinica , 2013, 48: 1644-1650.
15. Dual-modified liposomes with a two-photon-sensitive cell penetrating peptide and NGR ligand for siRNA targeting delivery. Biomaterials , 2015, 48: 84-96.
16. Co-encapsulation of paclitaxel and baicalein in nanoemulsions to overcome multidrug resistance via oxidative stress augmentation and P-glycoprotein inhibition. International Journal of Pharmaceutics, 2016, 513: 8-16.
17. Vitamin E-rich nanoemulsion enhances the antitumor efficacy of low-dose paclitaxel by drivingTh1 immune response. Pharmaceutical Research , 2017, 34: 1244-1254.
