YANG Yajun
Educational background
09/2005 -07/ 2010 Peking Union Medical College, Medicinal Chemistry, Doctor
09/2001 –07/2005 Hebei Medical University, pharmacy, Bachelor
Work experience
05/2014 - present Institute of Materia Medica, Chinese Academy of Medical Sciences, Associate professor
07/2010 - 05/2014 Institute of laboratory animal sciences, Chinese Academy of Medical Sciences, Assistant professor
1. Synthesis and antiviral activity of lycorine derivatives. Journal of Asian Natural Products Research , 2020, 22(12): 1188-1196.
2. Design, synthesis and biological evaluation of triaryl compounds as novel 20S proteasome inhibitors. Bioorg Med Chem Lett , 2020, 30(21):127508.
3. Evodiamine derivatives improve cognitive abilities in APPswe/ PS1ΔE9 transgenic mouse models of Alzheimer's disease. Animal Models and Experimental Medicine , 2020, 3(3):193-199.
4. Condensation of anthranilic acids with pyridines to furnish pyridoquinazolones via pyridine dearomatization. Chem Comm , 2016, 52(87): 12869-12872 .
5. Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells. Bioorg Med Chem Lett , 2015, 35(17): 3526-3528.
6. Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice. Mar. Drugs , 2014, 12, 4086-4095.
7. Chebulagic acid, a hydrolyzable tannin, exhibited antiviral activity in vitro and in vivo against human enterovirus 71. International Journal of Molecular Science , 2013, 14(5): 9618-9627.
8. Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo. Phytomedicine , 2012, 20(1): 67-70.
9. Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo. Bioorg Med Chem Lett , 2012, 22(6):2209-2211.
10. Synthesis and cytotoxic activity of heterocyclic ring-substituted phthalimide derivatives. Chin Chem Lett , 2010, 21(8): 902-904.
