YANG Licheng
Licheng got his PhD from National University of Singapore, where he investigated asymmetric catalysis under the supervision of Prof. ZHAO Yu. Then he moved to Hans Renata group at Scripps Research Institute to study the chemoenzymatic synthesis. In 2022, Licheng started his independent career at IMM, China. His research interest focuses on chemoenzymatic synthesis of drug molecules and bioactive natural products, including the discovery, evolution and application of enzymes, as well as incorporate both chemosynthesis and enzymatic catalysis into the precise synthesis strategy.
1. Yang, L.-C.; Deng, H.; Renata, H. “Recent Progress and Developments in Chemoenzymatic and Biocatalytic Dynamic Kinetic Resolution” Org. Process Res. Dev. 2022, 26 , 1925-1943.
2. Li, F.;# Yang, L.-C.;# Zhang, J.; Chen, J. S.; Renata, H.* “Diastereoselective Synthesis of β-Branched α-Amino Acids via Biocatalytic Dynamic Kinetic Resolution,” Angew. Chem., Int. Ed. 2021, 60 , 17680-17685. (Co-first author)
3. Huang, Y.; Ma, C.; Liu, S.; Yang, L.-C.; Lan, Y.;* Zhao, Y.* “Ligand Coordination/Dissociation-Induced Divergent Allylic Alkylations Using Alkynes," Chem. 2021, 7 , 812-826.
4. Zhang, X.; King-Smith, E.; Dong, L.-B.; Yang, L.-C.; Rudolf, J. D.; Shen, B.; Renata, H.* “Divergent Synthesis of Complex ent -Kauranes, ent -Atisanes and ent -Trachylobanes via a Hybrid Oxidative Approach,” Science , 2020, 369 , 799-806.
5. Yang L.-C.;# Wang, Y.-N.;# Liu, R.; Luo, Y.; Ng, X. Q.; Yang, B.; Rong, Z.-Q.; Lan, Y.;* Shao, Z.;* Zhao, Y.* “Stereoselective Access to [5.5.0] and [4.4.1] Bicyclic Compounds through Pd-Catalysed Divergent Higher-Order Cycloadditions,” Nat. Chem. 2020, 12 , 860-868.
6. Rong, Z.-Q.; Yu, Z.; Weng, C.; Yang, L.-C.; Lu, S.; Lan, Y.;* Zhao, Y.* “Dynamic Kinetic Asymmetric Amination of Alcohols Assisted by Microwave: Stereo-convergent Access to Tetralin- and Indane-Derived Chiral Amines," ACS Catal. 2020, 10 , 9464-9475.
7. Yang, L.-C.; Tan, Z. Y.; Rong, Z.-Q.; Liu, R.; Wang, Y.-N.; Zhao, Y.* “Pd-Titanium Relay Catalysis Enables Switch of Alkoxide-π-Allyl to Dienolate Reactivity for Spiro-Heterocycle Synthesis," Angew. Chem. Int. Ed. 2018, 57 , 7860-7864. (Featured in Synfacts)
8. Wang, Y.-N.;# Yang L.-C.;# Rong, Z.-Q.; Liu, T.-L.; Liu, R.; Zhao, Y.* “Pd-Catalyzed Enantioselective [6+4] Cycloaddition of Vinyl Oxetanes with Azadienes to Access Ten-Membered Heterocycles,” Angew. Chem., Int. Ed. 2018, 57 , 1596-1600. (Co-first author; featured in Synfacts; ESI highly cited paper)
9. Rong, Z.-Q.;# Yang, L.-C.;# Liu, S.; Yu, Z.; Wang, Y.-N.; Tan, Z. Y.; Huang, R.-Z.; Lan, Y.;* Zhao, Y.* “Nine-membered Benzofuran-Fused Heterocycles: Enantioselective Synthesis by Pd-Catalysis and Rearrangement via Transannular Bond Formation” J. Am. Chem. Soc. 2017, 139, 15304-15307. (Co-first author; featured in Synfacts)
10. Yang, L.-C.;# Rong, Z.-Q.;# Wang, Y.-N.; Tan, Z. Y.; Wang, M.; Zhao, Y.* “Construction of Nine-Membered Heterocycles through Palladium-Catalyzed Formal [5+4] Cycloaddition,” Angew. Chem. Int. Ed. 2017, 56, 2927-2931. (Featured in Synfacts; ESI highly cited paper)
11. Yang, L.-C.; Wang, Y.-N.; Zhang, Y.;* Zhao, Y.* “Acid-Assisted Ru-Catalyzed Enantioselective Amination of 1,2-Diols through Borrowing Hydrogen,” ACS Catal. , 2017, 7 , 93-97. (Featured in Synfacts)
Huang, Y.; Yang, L.; Shao, P.; Zhao, Y.* “Practical, Highly Stereoselective Allyl- and Crotylsilylation of Aldehydes Catalyzed by Readily Available Cinchona Alkaloid Amide," Chem. Sci. 2013, 4 , 3275-3281.
