XU Shu
Principal Investigator
Xu Shu got his bachelor's degree from the department of chemistry, Peking University in 2002 and the Ph.D. degree from the graduate school of science, Nagoya University, Japan in 2009. From 2009 to 2014, he joined the graduate school of life sciences, Tohoku University, Japan. In June 2014, he started his independent research as an associate professor in the department of synthetic medicinal chemistry, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College.
His research interest mainly focuses on the total synthesis of structurally complex bioactive natural products, especially the target molecules with caged carbon skeletons. Other interests include the development of organic synthetic methodologies with wide substrate-scope and practicability, innovative drug discovery, and new route development for drug synthesis and drug impurity synthesis.
1. Strategies and efforts towards the total synthesis of palhinine alkaloids. Molecules , 2020, 25(18): 4211.
2. Toward the total synthesis of grayanane diterpene mollanol A by a Prins [3 + 2] strategy. Organic & Biomolecular Chemistry , 2020, 18(10): 1877–1880.
3. K2S2O8-mediated radical cyclisation of 2-alkynylthioanisoles or -selenoanisoles: a green and regioselective route to 3-nitrobenzothiophenes and benzoselenophenes. RSC Advances , 2020, 10(32): 19083–19087.
4. Synthesis of the tricyclic caged core of palhinine alkaloids based on a non-Diels−Alder-type strategy. Organic Letters , 2019, 21(14): 5567–5569.
5. Combination of PhI(OAc)2 and 2‑Nitropropane as the source of methyl radical in room-temperature metal-free oxidative decarboxylation/cyclization: Construction of 6‑methyl phenanthridines and 1‑methyl isoquinolines. Journal of Organic Chemistry , 2018, 83(24): 15415–15425.
6. Use of unprotected amino acids in metal-free tandem radical cyclization reactions: divergent synthesis of 6-alkyl/acyl phenanthridines. RSC Advances , 2017, 7(88): 55891–55896.
7. Separation of alkyne enantiomers by chiral column HPLC analysis of their cobalt-complexes. Molecules , 2017, 22(3): 466
8. Strategies for construction of the all-carbon macrocyclic skeleton of the ansamycin antibiotic—kendomycin. Journal of Antibiotics , 2016, 69(4): 202–213.
9. Total synthesis of the antibiotic kendomycin: A macrocyclization using the Tsuji–Trost etherification. Angewandte Chemie International Edition , 2014, 53(16): 4213–4216.
10. Unexpected dehomologation of primary alcohols to one-carbon shorter carboxylic acids using o -iodoxybenzoic acid (IBX). Chemical Communications , 2014, 50(21): 2758–2761.
11. Enantioselective total synthesis of pinnaic acid and halichlorine. Chemistry-An Asian Journal , 2014, 9(1): 367–375.
12. Pinnarine, another member of the halichlorine family. Isolation and preparation from pinnaic acid. Journal of Natural Products , 2011, 74(5): 1323–1326.
13. One-pot reductive cleavage of exo -olefin to methylene with a mild ozonolysis-Clemmensen reduction sequence. Tetrahedron Letters , 2010, 51(34): 4534–4537.
14. Asymmetric total synthesis of pinnaic acid. Angewandte Chemie International Edition , 2007, 46(30): 5746–5749.
