XIE Kebo
Dr. Xie received his B.S. (2010) and M.S. (2012) from Shandong University and Ph.D. (2015) from the Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College under the guidance of Prof. Jungui Dai. After that, he joined the faculty of IMM, CAMS & PUMC. His research interests focus on biosynthesis and biocatalysis of medicinal natural products, including: 1. Identifying the key enzymes and elucidating their catalytic mechanisms in the biosynthesis of complex medicinal natural products; 2. Using molecular biological methods to broaden the substrate spectrum of enzymes and develop tool enzymes for synthesis of target molecules; 3. Building artificial biosynthesis pathway to produce bioactive natural products and drugs. He has authored and co-authored over 30 scientific publications including Nature Communications, Nature Chemistry, Organic Letters, Advanced Synthesis & Catalysis, Journal of Agricultural and Food Chemistry and Applied and Environmental Microbiology.
1. Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides. Nature Communications , 2020, 11, 1-12.
2. FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis. Nature Chemistry , 2020, 12, 620–628. doi: 10.1038/s41557-020-0467-7.
3. Enzymatic Synthesis of Bioactive O-Glucuronides Using Plant Glucuronosyltransferases. Journal of Agricultural and Food Chemistry , 2019, 67, 6275-6284.
4. Enzymatic N-Glycosylation of Diverse Arylamine Aglycones by a Promiscuous Glycosyltransferase from Carthamus tinctorius. Advanced Synthesis & Catalysis , 2017, 359, 603‒608.
5. Molecular Characterization and Phylogenetic Analysis of Two Novel Fungal Phenolic UDP-Glycosyltransferases from Absidia coerulea and Rhizopus japonicus. Applied and Environmental Microbiology , 2017, AEM-03103.
6. Enzymatic glucosylation of unnatural naphthols by a promiscuous glycosyltransferase from Aloe arborescens. Tetrahedron Letters , 2017, 58, 2118‒2121.
7. Nicotine dehydrogenase complexed with 6-hydroxypseudooxynicotine oxidase involved in the hybrid nicotine-degrading pathway in Agrobacterium tumefaciens S33. Applied and Environmental Microbiology , 2016, 82, 1745‒1755.
8. Probing the catalytic promiscuity of a regio- and stereospecific C-glycosyltransferase from Mangifera indica.. Angewandte Chemie International Edition , 2015, 54, 12678‒12682.
9. Exploring the catalytic promiscuity of a new glycosyltransferase from Carthamus tinctorius. Organic Letters , 2014, 16, 4874-4877.
