WANG Yuehua
Principal Investigator
From July 2003 to the present, Dr. Wang Yuehua has been working at National Centre for Pharmaceutical Screening, mainly engaged in drug target confirmation, drug screening model establishment and screening, drug evaluation and mechanism research of active compounds. In recent years, she has presided and participated in a number of national projects. Main research results: participation in several preclinical drug studies and obtained clinical research approval documents; more than 80 papers published; more than 10 patents authorized or applied for; participation in writing more than 10 books; five provincial and ministerial awards awarded for scientific research achievements.
1. Chrysomycin A Attenuates Neuroinflammation by Down-Regulating NLRP3/Cleaved Caspase-1 Signaling Pathway in LPS-Stimulated Mice and BV2 Cells. Int. J. Mol. Sci. 2021, 22(13), 6799;
2. Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/ reperfusion rats. Apoptosis, 2020, 25:354–369.
3. Dynamic alterations of brain Injury, functional recovery, and metabolites profile after cerebral ischemia/reperfusion in rats contributes to potential biomarkers. J Mol Neurosci, 2020, 70: 667–676.
4. Cerebral ischemia-reperfusion aggravated cerebral infarction injury and possible differential genes identified by RNA-Seq in rats. Brain Res Bull, 2020, 156: 33-42.
5. Esculin alleviates acute kidney injury and inflammation induced by LPS in mice and its possible mechanism. J.Chin. Pharm. Sci. 2020, 29 (5)322–332.
6. Myricitrin blocks activation of NF-κB and MAPK signaling pathways to protect nigrostriatum neuron in LPS-stimulated mice. J Neuroimmunol, 2019, 337:57049. doi.org/10.1016/j.jneuroim.2019.577049.
7. Kaempferol attenuates neuroinflammation and blood brain barrier dysfunction to improve neurological deficits in cerebral ischemia/reperfusion rats. Brain Res, 2019, 1722: 146361. doi: 10.1016/j.brainres.2019.146361.
8. Xiao-Xu-Ming decoction extract alleviates LPS-induced neuroinflammation associated with down-regulating TLR4/MyD88 signaling pathway in vitro and in vivo. J Chin Pharm Sci, 2019, 28 (2): 88-99.
9. Kaempferol attenuates LPS-induced striatum injury in mice involving anti-neuroinflammation, maintaining BBB integrity, and down-regulating the HMGB1/TLR4 pathway. Int J Mol Sci, 2019, 20: 491. doi:10.3390/ijms20030491.
10. Xiao-Xu-Ming decoction extract regulates differentially expressed proteins in the hippocampus after chronic cerebral hypoperfusion. Neural Regen Res, 2019, 14(3): 470-479.
11. Xiao-Xu-Ming decoction extract alleviates LPS-induced neuroinflammation associated with down-regulating TLR4/MyD88 signaling pathway in vitro and in vivo. J. Chin. Pharm. Sci. 2019, 28 (2): 88-99.
12. Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4/MyD88 pathway. Int Immunopharmacol, 2018, 56:29-35.
13. Ramulus Cinnamomi extract attenuates neuroinflammatory responses via downregulating TLR4/MyD88 signaling pathway in BV2 cells. Neural Regen Res, 2017, 12(11): 1860-1864.
14. Esculin improves dyslipidemia, inflammation responses and renal damage in streptozotocin-induced diabetic rats. BMC Complement Altern Med, 2015, 15(1):402.
15. Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production. Evid Based Compl Alter, 2015, 2015: 189239.
1. Towards the road of drug innovation: review of 1035 project implementation. Edited by Chen Chuanhong and Chen Kaixian. Higher Education Press. ISBN 978-7-04-052199-3.
2. Review on the ancient and modern research of traditional Chinese medicine "poison". Edited by Du Guanhua. China Medical Science and Technology Press. ISBN 978-7-5214-0668-9.
3. Natural small molecule drugs-small molecule drugs derived from plants. Edited by Du Guanhua. People's Health Publishing House. ISBN 978-7-117-24870-9.
4. Twenty years of modernization of traditional Chinese medicine (1996-2015). Edited by Zhang Boli and Chen Chuanhong. Shanghai Science and Technology Press. ISBN 978-7-5478-3271-4.
1. 2019. Chinese Medical Science and Technology Award, the second prize. Chinese Medical Association. China.
2. 2017. Chinese Medical Science and Technology Award, the third prize. Chinese Medical Association. China.
3. 2013. Beijing Science and Technology Progress Award, the third prize. Beijing Municipal Commission of Science and Technology, China.
4. 2011. Chinese Medical Science and Technology Award, the third prize. Chinese Medical Association. China.
5. 2009. Beijing Science and Technology Award, the second prize. People's Government of Beijing Municipality. China.
