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WANG Yanan
Associate Professor

Department :

Department of Pharmaceutical Analysis

Platform :

Contact Details

He Wenyi's group
wangyanan@imm.ac.cn
Brief Introduction

Wang Yanan graduated from Peking Union Medical College in July 2012 with a doctorate degree in medicinal chemistry. In August 2012, he worked in the Department of Pharmaceutical Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences. Mainly engaged in the application and innovation of new technologies and methods of Nuclear Magnetic Resonance analysis in the development of new drugs, and established a leading active structure-oriented application analysis strategy based on the HPLC-NMR combined technology to discover the active substances from natural products. Currently undertaking the postgraduate courses of "Spectral Analysis (Masters)" and "Medicinal Chemistry Experiment" of Peking Union Medical College. He has published more than 50 domestic papers, more than 30 SCI papers, obtained one authorized patent, and applied for one patent. Participated in the preparation of the scientific research tool "Handbook of Analytical Chemistry. 7A. Hydrogen-1 Nuclear Magnetic Resonance Spectroscopy" (Third Edition)".

Achievements

Papers

1. Nine sesquiterpenoid dimers with four unprecedented types of carbon skeleton from Chloranthus henryivar. hupehensis. Organic Chemistry Frontiers 2021 (online).

2. Xanthanoltrimer A–C: three xanthanolide sesquiterpene trimers from the fruits of Xanthium italicum Moretti isolated by HPLC-MS-SPE-NMR. Organic Chemistry Frontiers 2021, 8 (6), 1288-1293.

3. A fast strategy for profiling and identifying pharmaceutic excipient polysorbates by ultra-high performance liquid chromatography coupled with high-resolution mass   spectrometry. J Chromatogr A 2020, 1609, 460450.

4. Insight into Medicinal Chemistry Behind Traditional Chinese Medicines: p-Hydroxybenzyl Alcohol-Derived Dimers and Trimers from Gastrodia elata. Natural Products and Bioprospecting 2020, 11, (1), 31-50.

5. Trichodestruxins A–D: Cytotoxic Cyclodepsipeptides from the Endophytic Fungus Trichoderma harzianum. Journal of Natural Products 2020, 83, (12), 3635-3641.

6. Enzymatic Intermolecular Hetero-Diels-Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes. J Am Chem Soc 2019, 141 (36), 14052-14056.

7. Crystal   structure of dimethyl 3,12-dibenzyl-6,10-diphenyl-3,12-diazapentacyclo [6.3.1.02.7.04.11.05.9]-dodecane-7,11-dicarboxylate - acetone (2/1),   C40H38N2O2 ⋅ 0.5C3H6O. Zeitschrift   für Kristallographie - New Crystal Structures 2019, 234, (6), 1163-1166.

8. New glycosides from the twigs and leaves of Rhododendron latoucheae. Journal of Asian natural products research 2019, 21, (4), 299-307.

9. Triterpenoids from the twigs and leaves of Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR. Tetrahedron   2019, 75, (2), 296-307.

10. Purpurolide A, 5/5/5 spirocyclic sesquiterpene lactone in Nature from the endophytic fungus Penicillium purpurogenum. Organic letters 2018, 20,   (22), 7341-7344.

11. Diphenyl Ethers from a Marine-Derived Aspergillus sydowii. Mar. Drugs 2018, 16, 451.

Books

Handbook of Analytical Chemistry. 7A. Hydrogen-1. Deng, A.-J., Li, Q., Qin, H.-L., Song, L. and Wang, Y.-N. etal, Edited by Qin, H.-L., Yu, D.-Q. Chemical Industry Press, Print ISBN: 978-7-122-27858-6.


Honors & Awards