WANG Shoubao
Wang Shoubao has been working in the center since 2009. He has presided over 2 NSFC projects and 1 general project of Beijing NSFC after returning to China from the University of Manchester in 2015. He has participated in many research projects such as "major new drug creation" major scientific and technological special project, national key research and development plan, medical and health science and technology innovation project of Chinese Academy of Medical Sciences, etc. Wang has participated in the R-&-D and application process of new drugs including neonitrendipine tablets and salvianolic acid A tablets. He has published more than 30 research papers in Nat commun, Br J pharma., Acta pharma Sinica B and other well-known journals at home and abroad, applied for 6 national invention patents, and participated in the editing (translation) of more than 10 works.
1. Total Flavonoids from Anchusa italica improves cardiac function and attenuates cardiac remodeling post-myocardial infarction in mice. Journal of Ethnopharmacology. 2020; 257:112887
2. Formononetin ameliorates myocardial ischemia/reperfusion injury in rats by suppressing the ROS-TXNIP-NLRP3 pathway. Biochemical and Biophysical Research Communications. 2020;525(3):759-766.
3. Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling. Nat Commun. 2017;8(1):494-509.
4. Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway. Br J Pharmacol. 2016; 173(15):2402-18.
5. Pinocembrin protects rat against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids. Chinese Journal of Natural Medicines. 2013, 11(3):0207-13.
6. EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway. Acta Pharmaceutica Sinica B. 2013, 3(1): 25–31.
7. Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. J Asian Nat Prod Res. 2012, 14(11): 1084-92.
8. Effect of salvianolic acid A on vascular reactivity of streptozotocin-induced diabetic rats. Life Sci. 2010;85(13-14):499-504.
9. Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats. Eur J Pharmacol. 2009; 615(1-3):125-32.
10. Antihyperuricemiceffect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidaseactivity and urate transporter 1 expression in mice. Acta Pharmaceutica Sinica B. 2018;8(2):306–315.
11. Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor. Biosci Trends. 2015;9(6):367-76.
12. Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. Atherosclerosis. 2013;231(2):384-91.
13. Puerarin protects against myocardial ischemia-reperfusion injury by Inhibition of NLRP3 inflammasome through TLR4/MyD88/NF-Κb pathway in rats. Acta Pharmaceutica Sinica, 2021.
14. .Danshenyin granule inhibits NLRP3 inflammasome and prevents myocardial ischemia reperfusion injury in rats. Pharmacology and Clinics of Chinese Materia Medica, 2021.
15. Establishment and application of a high throughput screening model for hamster chymotrypsin 2 inhibitors. Acta Pharmaceutica Sinica, 2012;47 (2): 168-173.
16. High throughput screening of human soluble epoxide hydrolase inhibitors. Acta Pharmaceutica Sinica, 2010 (11): 1367-72.
1. Experimental Pharmacology (2nd Ed). Wang, S., and Li, F. Edited by Du, G. Higher Education Press, Pages 83-100. 2021. ISBN: 978-7-04-054780-1.
2. The 2019 Annual Report of Medical Science and Technology Development in China. Wang, S., Lv, Y., and Du, G. Edited by Wang, C. Science Press, Pages113-121. 2020. ISBN: 9787030670809.
3. Pharmacological advances in natural product drug discovery. Wang, S., Fang, L., and Du G. Edited by Du, G. Academic Press, 2020. ISBN: 978-0-12-820185-5.
4. Natural Small Molecule Drugs from Plants. Wang, S., and Du G. Edited by Du, G. Springer Press, 2019. ISBN: 978-981-10-8022-7.
5. The 2018 Annual Report of Medical Science and Technology Development in China. Wang, S., Lv, Y., and Du, G. Edited by Wang, C. and Wu, P. Science Press, Pages 113-121. 2019. ISBN: 9787030670809.
6. Overview of ancient and modern research on the toxicity of Traditional Chinese medicinal materials. Wang, S., and Du G. Edited by Du, G. China Medical Science Press, 2019. ISBN: 978-7-5214-0668-9.
7. Natural small molecule drugs-small molecule drugs from plants (Chinese). Wang, S., and Du G. Edited by Du, G. People's Medical Publishing House, 2019. ISBN: 9787117248709
8. The 2017 Annual Report of Medical Science and Technology Development in China. Wang, S., Lv, Y., and Du, G. Edited by Cao, X., Wang, C. and Li, G. Science Press, Pages 113-121. 2018. ISBN: 9787030564689.
9. Goodman & Gilman's The Pharmacological Basis of Therapeutics (12th Ed). Wang, S., Fang, L., and Du G. Edited by Jin, Y., and Li, D. People's Medical Publishing House, 2016. ISBN: 9787509137444.
10. The Chemistry, Pharmacology and Clinical Therapeutic Effects of Danshen. Wang, S., Fang, L., and Du G. Edited by Zhang, J. and Du, G. Chemical Industry Press, 2013. ISBN: 9787122174819.
1. 2019, Chinese Medical Science and Technology Award, the second prize. China.
2. 2018, The 22nd China Pharmacology Society-Servier Young Investigator Awards in Pharmacology.
3. 2017, Chinese Medical Science and Technology Award, the third prize. China.
4. 2012, Natural Science Award from Ministry of Education, the 2nd prize. China.
