WANG Dongmei
Wang Dongmei graduated from Peking Union Medical College in 2009 with a doctoral degree in medicinal chemistry. Since August 2009, she has been working at the Institute of Materia Medica, Chinese Academy of Medical Sciences, mainly engaged in chemical biology research of effective ingredients of Chinese herbal medicine and the research and development of innovative drugs.
She has presided over or participated in a number of scientific research projects. Wang has applied for 17 invention patents at home and abroad, seven of which have been authorized. More than 30 papers have been published in domestic and overseas professional journals. She has rich experience in new drug research and development.
1. Chemoproteomics identifies Ykt6 as the direct target of Schisandrin A for neuroprotection. Tiantian Wang, Yu Zhou, Hao Zheng, Tao Shen, Dongmei Wang*, Jinlan Zhang*. Chin Chem Lett . 2022;107887. https://doi.org/10.1016/j.cclet.2022.107887.
2. Celastrol Targets Cullin-Associated and Neddylation-Dissociated 1 to Prevent Fibroblast-Myofibroblast Transformation against Pulmonary Fibrosis. Yu Zhou#, Manru Li#, Tao Shen, Tianming Yang, Gaona Shi, Yazi Wei, Chengjuan Chen, Dongmei Wang*, Yanan Wang*, Tiantai Zhang*. ACS Chem Biol . 2022;17(10):2734-2743. doi:10.1021/acschembio.2c00099.
3. Nintedanib exerts anti-pulmonary fibrosis activity via inhibiting TANK-binding kinase 1 (TBK1) phosphorylation. Manru Li, Yu Zhou, Tiantian Wang , Menglin Li, Xiong Chen , Tiantai Zhang, Dongmei Wang*, Jinlan Zhang*. Chem Commun . 2022;58(8):1199-1202. doi:10.1039/d1cc05621b.
4. Harnessing affinity-based protein profiling to reveal a novel target of nintedanib, Xiong Chen#, Menglin Li#, Manru Li, Dongmei Wang*, Jinlan Zhang*, Chem Commun., 2021, 57, 3139-3142, doi: 10.1039/d1cc00354b.
5. Global profiling and identification of bile acids by multi-dimensional data mining to reveal a way of eliminating abnormal bile acids. Lin Mζ, Chen Xζ, Wang Z, Wang D*, Zhang JL*. Anal Chim Acta., 2020;1132:74-82., doi:10.1016/j.aca.2020.07.067.
6. Design, synthesis, and evaluation of novel isoflavone derivatives as multifunctional agents for the treatment of Alzheimer‘s disease. Wang DMζ, Hu Mζ, Li XP, Zhang D, Chen CJ, Fu JM, Shao S, Shi GN, Zhou Y, Wu S*, Zhang TT*. Eur J Med Chem, 2019, 168: 207-220. doi: 10.1016/j.ejmech.2019.02.053.
7. Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists.Xin J, Hu M, Liu Q, Zhang TT, Wang DM*, Wu S*. J Enzyme Inhib Med Chem. 2018;33(1):1545-1553. doi:10.1080/14756366. 2018.1509212.
8. Design, synthesis, biological evaluation, and molecular docking of novel flavones as H3 R inhibitors. Wen Gζ, Liu Qζ, Hu HB, Wang DM*, Wu S*. Chem Biol Drug Des. 2017;90(4):580-589. doi:10.1111/cbdd.12981.
9. Design, Synthesis, and Biological Evaluation of a New Series of Biphenyl/ Bibenzyl Derivatives Functioning as Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase. Molecules. Wang DM, Feng B, Fu H, Liu AL, Wang L, Du GH, Wu S*. 2017;22(1):172. doi:10.3390/molecules 22010172.
10. Wuzi Yanzong pill, a Chinese polyherbal formula, alleviates testicular damage in mice induced by ionizing radiation. Ji HJζ, Wang DMζ, Wu YP, Niu YY, Jia LL, Liu BW, Feng QJ, Feng ML. BMC Complement Altern Med. 2016;16(1): 509. doi:10.1186/ s12906-016-1481-6.
