TIAN Yulin
Dr. Tian Yulin completed his undergraduate degree in pharmacy from Shenyang Pharmaceutical University in 2010 and his Ph.D. in medicinal chemistry from Peking Union Medical College in 2015. After completing postdoctoral work at University at Buffalo, the State University of New York, he joined the Institute of Materia Medica, Chinese Academy of Medical Sciences as an associate professor. Dr. Tian's research interests focus on chemical biology and medicinal chemistry, including (i) development of bioorthogonal reaction-based molecular probes and their application in biomolecule labeling, modification and function modulation; (ii) target identification of bioactive molecules by chemoproteomics; (iii) structure-based molecular design, synthesis and biological evaluation. Dr. Tian has published more than 20 research papers in J. Am. Chem. Soc., Org. Lett., Chem. Commun., ACS Chem. Biol, et al.
1. Design of Nitroso-Modified Naphthylene-Based Fluorophores as Photoactivatable Bioorthogonal Turn-On Probes. Org. Lett., 2021, 23(9): 3782-3787.
2. Intracellular bioorthogonal labeling of glucagon receptor via tetrazine ligation. Bioorg. Med. Chem., 2021, 43: 116256.
3. Design of Hydrazone-Modified 1,8-Naphthalimides as Fluorogenic Click Probes Based on Nitrile Imine-Alkyne Cycloaddition. Eur. J. Org. Chem., 2020(2020): 4296–4300.
4. Development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling. Chem. Commun., 2019, 55(85): 12865-12868.
5. Fitness Factors for Bioorthogonal Chemical Probes. ACS Chem. Biol., 2019, 14(12): 2489−2496.
6. Design of stapled oxyntomodulin analogs containing functionalized biphenyl cross-linkers. Tetrahedron, 2019, 75(2): 286-295.
7. Recent Development of Photo-Cross-Linkers as Tools for Biomedical Research. Chimia, 2018, 72(11): 758-763.
8. Genetic encoding of 2-aryl-5-carboxytetrazole-based protein photo-cross-linkers. Chem. Commun., 2018, 54(35): 4449-4452.
9. Genetically encoded 2-aryl-5-carboxytetrazoles for site-selective protein photo-cross-linking. J. Am. Chem. Soc., 2017, 139(17): 6078–6081.
10. Synthesis of dihydrobenzoheterocycles through Al(OTf)3-mediated cascade cyclization and ionic hydrogenation. J. Org. Chem., 2014, 79(20): 9678-9685.
11. Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design. Eur. J Med. Chem., 2014, 85: 1-15.
12. One-pot synthesis of 4-methylisoquinolines via sequential Pd-catalyzed Heck reaction and intramolecular cyclization. Org. Biomol. Chem., 2013, 11(42): 7262-7266.
13. Design, synthesis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P1) receptor. Med Chem Comm., 2013, 4(9): 1267-1274.
