SUN Lan
Principal Investigator
Dr. Sun Lan is currently PI at the Institute of Materia Medica, CAMS & PUMC. She received her BA degree in 2003 from the School of Public Health Fudan University and her Ph.D. degree in 2010 from the Institute of Materia Medica, Peking Union Medical College. Sun's research interest is in cardiovascular pharmacology, and she is committed to exploring the frontiers of the discipline. She uses new technologies such as artificial intelligence to carry out original research on cardiovascular epigenetic mechanisms and the development of smart drugs. So far, she has published over 50 peer-reviewed papers in international journals such as Signal Transduct Target Ther, Theranostics, ATVB, Aging research review, etc.
1. Bexarotene combined with lapatinib for the treatment of Cushing‘s disease: evidence based on drug repositioning and experimental confirmation. Signal Transduct Target Ther. 2020 ;5(1):175.
2. miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism. Theranostics. 2020;10(12):5581-5599.
3. A Novel Co-Crystal of Bexarotene and Ligustrazine Improves Pharmacokinetics and Tissue Distribution of Bexarotene in SD Rats. Pharmaceutics. 2020 12(10):E906
4. Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases via Functioning as an miRNA Sponge. Mol Ther Methods Clin Dev. 2020 18:215-229.
5. Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients. Arterioscler Thromb Vasc Biol. 2016, 36:1386-97.
6. Prevention of vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia by CREB-mediated p21 induction: An insight from a plant polyphenol. Biochem Pharmacol. 2016;103:40-52.
7. CREB is activated in smooth muscle cells isolated from atherosclerotic plaques and reduces smooth muscle cell proliferation via p21-dependent mechanism. Int J Cardiol. 2014;174(3):764-7.
8. Association of circulating levels of asymmetric dimethylarginine (ADMA) with carotid intima-media thickness: evidence from 6168 participants. Ageing Res Rev. 2013, 12(2):699-707.
9. Endothelial dysfunction--an obstacle of therapeutic angiogenesis. Ageing Res Rev. 2009, 8(4):306-13.
