LIU Luping
Principal Investigator
Luping obtained her bachelor (2010) and master degree (2013) from Lanzhou University in China. Then she headed for Germany to pursue Ph.D. in Organic Chemistry (2013–2017) under the supervision by Prof. Benjamin List at Max Planck Institute for Coal Research, where she has established high enantioselectivities and reactivities in the challenging asymmetric transformations between inexpensive unactivated carbonyls and simple alkenes and achieved valuable scented compounds. In 2018, Luping moved into the field of chemical biology as a postdoc researcher with Prof. Neal Devaraj at University of California, San Diego, where she developed precision tetrazine ligations and de novo synthesis of natural lipid under aqueous conditions. She joined Peking Union Medical College as Assistant Professor at the beginning of 2022.
Our research interest has been focused on the interdisciplinary fields between fundamental organic chemistry and modern biotechnology: 1) Precision chemical tools: develop bioorthogonal chemical methods with high spatiotemporal control and aim for precision diagnostic and therapy. 2) Bioorthogonal catalysis: mimicking the living organisms, discover robust biocompatible catalytic system for targeting drug delivery. We have published high-impact journals such as Nat. Chem. , J. Am. Chem. Soc. , Angew. Chem., which were highlighted by CE&N and other international academic media.
1. Luping Liu; Dongyang Zhang; Mai Johnson; Neal K. Devaraj*. Light-activated tetrazines enable precision live-cell bioorthogonal chemistry, Nature Chemistry , 2022, 14: 1078–1085.
2. Dongyang Zhang; Luping Liu; Shuaijiang Jin; Ember Tota; Zijie Li; Xijun Piao; Xuan Zhang; Xiang-Dong Fu; Neal K. Devaraj*. Site-Specific and Enzymatic Cross-Linking of sgRNA Enables Wavelength-Selectable Photoactivated Control of CRISPR Gene Editing, Journal of the American Chemical Society , 2022, 144(10): 4487–4495.
3. Luping Liu; Yike Zou; Ahanjit Bhattacharya; Dongyang Zhang; Susan Q. Lang; K. N. Houk; Neal K. Devaraj*. Enzyme-free synthesis of natural phospholipids in water, Nature Chemistry , 2020, 12: 1029–1034.
4. Luping Liu; Hyejin Kim; Youwei Xie; Christophe Farés; Philip S. J. Kaib; Richard Goddard; Benjamin List*. Catalytic Asymmetric [4+2] Cycloaddition of Dienes with Aldehydes, Journal of the American Chemical Society , 2017, 139(39): 13656–13659.
5. Luping Liu#; Philip S. J. Kaib#; AurélienTap; Benjamin List*. A General Catalytic Asymmetric Prins Cyclization, Journal of the American Chemical Society , 2016, 138(34): 10822–10825.
6. Sayantani Das#; Luping Liu#; Yiying Zheng; M. Wasim Alachraf; Walter Thiel*; Chandra Kanta De*; Benjamin List*. Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet-Spengler Reaction, Journal of the American Chemical Society , 2016, 138(30): 9429–9432
7. Luping Liu; Markus Leutzsch; Yiying Zheng; M. Wasim Alachraf; Walter Thiel; Benjamin List*. Confined Acid-Catalyzed Asymmetric Carbonyl-Ene Cyclization, Journal of the American Chemical Society , 2015, 137(41): 13268–13271.
8. Luping Liu; Dekui Zhang; Panpan Zhang; Xianxing Jiang*; Rui Wang*. Catalytic highly asymmetric 1,5(6)-selective cyclization reaction of α-hydroxyimino cyclic ketones: direct approach to ring-fused hydroxyimino dihydropyrans, Organic and Biomolecular Chemistry , 2013, 11: 5222–5225.
9. Xianxing Jiang*; Luping Liu; Panpan Zhang; Yuan Zhong; Rui Wang*. Catalytic Asymmetric β,γ Activation of α,β-Unsaturated γ-Butyrolactams: Direct Approach to β,γ-Functionalized Dihydropyranopyrrolidin-2-ones, Angewandte Chemie International Edition , 2013, 52(43): 11329–11333.
10. Luping Liu; Yuan Zhong; Panpan Zhang; Xianxing Jiang*; Rui Wang*. The Core Scaffold-Inspired Stereoselective Synthesis of Spiropyrazolones via an Organocatalytic Michael/Cyclization Sequence, Journal of Organic Chemistry , 2012, 77(22): 10228–10234.
1. Thieme Chemistry Journals Award 2023
2. Beijing Nova Program 2022
3. Turck Prize 2017
4. 2017 CGCA Young Researchers Award (First Class)
5. 2016 Chinese Government Award for Outstanding Self-financed Students Abroad
