LI Xin
Xin Li received his Ph.D. in Analytical Chemistry from Dalian Institute of Chemical Physics, Chinese Academy of Sciences in 2008. In 2010, Dr. Xin Li went to Purdue University for postdoctoral training. He applied novel mass spectrometric methodologies in chemical synthesis and analysis of organic molecules which were patented in the US and in China.
Dr. Xin Li joined IMM as an associate professor in the summer of 2015. His research at IMM is center around the development and application of novel mass spectrometric methodologies in drug discovery and development process as well as in metabolite detection for early disease diagnostics. His research interests span a range of topics, including i) Fine measurement of drug distribution using ambient MS for studying of its metabolism, efficacy, pharmacological and toxicological effect, and action mechanism. ii) Recognition, spatial localization and annotation of metabolic signatures in tissue. iii) Biomarker discovery and elucidate their biological mechanism in brain disease. iv) Instrumentation for novel MS-based measurement methodologies with high sensitivity and high selectivity.
1. Chemical Derivatization for Mass Spectrometric Analysis of Metabolite Isomers. Progress in Chemistry , 2021, 33(3): 406-416.
2. Rapid Detection of Isocitrate Dehydrogenase Mutations in Human Gliomas Using Combination of Tissue Smears and Ambient Mass Spectrometry. Journal of Instrumental Analysis , 2021，40(2):263-269。
3. A novel sandwich method to prepare robust SPME polymer coating on glass slide with controllable thickness for direct analysis through fluorescence and MS imaging. Prog. Org. Coat. , 2021,151, 106076.
4. Virtual calibration quantitative mass spectrometry imaging for accurately mapping analytes across heterogeneous bio-tissue. Anal. Chem. , 2019, 91 (4): 2838-2846.
5. Spatially resolved metabolomics to discover tumor-associated metabolic alterations. Proc. Natl. Acad. Sci. USA. , 2019, 116(1): 52-57.
6. Whole-body spatially-resolved metabolomics method for profiling the metabolic differences of epimer drug candidates using ambient mass spectrometry imaging. Talanta , 2019, 202, 198-206.
7. A sensitive and wide coverage ambient mass spectrometry imaging method for functional metabolites based molecular histology. Adv. Sci. , 2018, 5(11): 1800250.
8. MassImager: A software for interactive and in-depth analysis of mass spectrometry imaging data. Anal. Chim. Acta , 2018, 1015: 50-57.
9. Quantitative analysis of drug distribution by ambient mass spectrometry imaging method with signal extinction normalization strategy and inkjet-printing technology. Talanta , 2018, 179, 230-237.
10. In situ Hydrogel Conditioning of Tissue Samples to Enhance the Drug’s Sensitivity in Ambient Mass Spectrometry Imaging. Anal. Chem. , 2017, 89, 6318-6323.
11. Functionalization of saturated hydrocarbons using nitrogen ion insertion reactions in mass spectrometry. Int. J. Mass Spectrom. , 2017, 418, 79-85.
12. Ambient Ionization Mass Spectrometry Measurement of Aminotransferase Activity. J. Am. Soc. Mass Spectrom. , 2017, 28, 1175-1181.
13. On-line reaction monitoring and mechanistic studies by mass spectrometry: Negishi cross-coupling, hydrogenolysis and reductive amination. Angew. Chem. Int. Ed. , 2014, 53, 5931-5935.
14. Chemical reactivity assessment using reactive paper spray mass spectrometry: Katritzky reaction. ChemPlusChem. , 2013, 78, 1142-1148.
15. Carbon–Carbon bond activation in saturated hydrocarbons by field-Assisted nitrogen fixation. Angew. Chem. Int. Ed. , 2013, 152, 1040-1043.
16. Direct analysis of steviol glycosides from Stevia leaves by ambient ionization mass spectrometry performed on whole leaves. Analyst , 2012, 137, 3091-3098.
