LIU Zhanzhu
Principal Investigator
Dr. Zhanzhu Liu, professor, doctoral supervisor, and excellent teacher of Peking Union Medical College. He graduated from the Department of Chemistry of Peking University with a bachelor's degree and a master's degree, and from Peking Union Medical College with a doctoral degree. In 1990, he worked in Hebei Institute of Materia Medica, and then went to Georgia Institute of Technology for further study. In 2002, he started working in the Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College and was appointed as doctoral supervisor in 2005, mainly engaged in innovative drug research and development, total synthesis of natural products, and organic synthesis methodology. He is also a member of the academic committee and an editorial board member of "Chinese Chemistry Letters". He has presided over a number of scientific research projects. Over the years, he has published more than 70 research papers, and applied for more than 10 invention patents, with 3 patents authorized.
1. Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors. European Journal of Medicinal Chemistry , 2021, 223: 113631-113645.
2. An improved total synthesis of griseofamine A. Tetrahedron Letters , 2021, 67: 152894-152895.
3. Synthesis and cytotoxicity of (−)-homorenieramycin G and its derivatives. Organic & Biomolecular Chemistry, 2020, 18: 9883-9894.
4. Design, synthesis and cytotoxicity of novel hexacyclic saframycin–ecteinascidin analogs. Organic & Biomolecular Chemistry, 2020, 18: 237-249.
5. Regioselective bromination of 6-hydroxytetrahydroisoquinolines. Journal of Heterocyclic Chemistry , 2020: 1-4.
6. Total synthesis and antibacterial activity evaluation of griseofamine A and 16- epi -griseofamine A. Organic Letters , 2019, 21(7): 2393-2396.
7. A novel specific peroxisome proliferator-activated receptor γ (PPARγ) modulator YR4-42 ameliorates hyperglycaemia and dyslipidaemia and hepatic steatosis in diet-induced obese mice. Diabetes Obesity & Metabolism , 2019: 2553-2563.
8. A concise synthesis of ( E )-3-aryl-2,3,4,5-tetrahydro-1 H- 3-benzazonines by aryne induced [2,3] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines. Organic & Biomolecular Chemistry, 2018, 16(40): 7393-7399 .
9. Synthesis of 3-aryl-3-benzazepines via aryne [1,2] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines. Organic Chemistry Frontiers, 2018, 5(11): 1798-1810 .
10. Synthesis and cytotoxicity of novel imidazo[4,5- d ]azepine compounds derived from marine natural product ceratamine A. Bioorganic & Medicinal Chemistry Letters , 2018, 28(5): 866-868.
11. Asymmetric synthesis of highly functionalized tyrosine derivatives for the construction of bistetrahydroisoquinoline alkaloids. Tetrahedron Letters , 2018, 59(31): 3029-3032.
12. Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings. Bioorganic & Medicinal Chemistry Letters , 2018, 28(18): 3050-3056.
13. Synthesis and cytotoxicity of a novel series of saframycin-ecteinascidin analogs containing tetrahydro-β-carbboline moieties. European Journal of Medicinal Chemistry , 2017, 135(28): 260-269.
14. Effective synthesis and cytotoxicity of novel microtubule-stabilizing agent ceratamine A analogues. Tetrahedron , 2017, 73(15): 2159-2171.
15. Stereoselective total synthesis of (±)-parthenolide and (±)-7-epiparthenolide. Tetrahedron , 2016, 72: 4346-4354.
16. Synthesis and biological evaluation of novel tetrahydroisoquinoline- C -aryl glucosides as SGLT2 inhibitors for the treatment of type 2 diabetes. European Journal of Medicinal Chemistry , 2016, 114: 89-100.
17. Synthesis of indolo[2,3-a]pyrrolo[3,4-c]carbazoles via the oxidative cyclization of bisindolylmaleimides with Pd(TFA)2/Cu(OAc)2. Journal of Heterocyclic Chemistry , 2015, 52: 911-913.
18. Asymmetric total synthesis of three stereoisomers of (-)-renieramycin G and their cytotoxic activities. Tetrahedron , 2015, 71: 4296-4303.
20. The preparation of novel chiral auxiliaries SAMIQ/RAMIQ and their application in the asymmetric Michael addition. Tetrahedron , 2014, 70: 4602-4610.
21. Synthesis and cytotoxic activities of a series of novel N-methyl-bisindolylmaleimide amide derivatives. Journal of Asian Natural Products Research , 2014, 3: 296-303.
22. Total synthesis of microtubule-stabilizing agent Ceratamine A. Journal of Organic Chemistry, 2013, 78: 12814-12818.
23. Synthesis and cytotoxicity of dinuclear platinum (II) complexes of (1S,3S)-1,2,3,4-tetrahydroisoquinolines. Chinese Chemical Letters , 2013, 24: 186-188.
24. Synthesis and cytotoxicity of 3-aryl acrylic amide derivatives of the simplified saframycin-ecteinascidin skeleton prepared from L-dopa. European Journal of Medicinal Chemistry , 2013, 62: 670-676.
25. Synthesis and cytotoxic activities of a series of novel N-methyl-bisindolylmaleimide amino acid ester conjugates. Chinese Chemical Letters , 2012, 23: 462-465.
26. Total synthesis and cytotoxicity of (-)-jorumycin and its analogues. Tetrahedron , 2012, 68: 2759-2764.
27. Asymmetric synthesis and cytotoxicity of (-)-saframycin A analogues. European Journal of Medicinal Chemistry , 2012, 49: 239-244.
28. Asymmetric total synthesis of (-)-saframycin A from L-tyrosine. Journal of Organic Chemistry , 2011, 76: 5363–5368.
29. Synthesis and cytotoxicity of (-)-renieramycin G analogues. Bioorganic & Medicinal Chemistry Letters , 2011, 21: 1419-1421.
30. Synthesis of an Isomer of the Renieramycin Skeleton from L-Tyrosine. Journal of Heterocyclic Chemistry , 2011, 48: 414-418.
31. Synthesis and cytotoxicity of cis-dichloroplatinum (II) complexes of (1S,3S)-1,2,3,4-tetrahydroisoquinolines. European Journal of Medicinal Chemistry , 2011, 46: 356-363.
