LIU Shuainan
Liu Shuainan's research program is divided into the R&D of natural products or chemicals-based novel anti-diabetic drugs and the basic research for diabetes pathogenesis and pharmacological mechanism. Basic investigation approaches include studies aimed at identifying new targets and mechanisms underlying the pathogenesis of type 2 diabetes, obesity, and other disorders of insulin resistance. A major focus for the basic research program is to understand the molecular and cellular mechanisms of SIRT5 action. An important emphasis is placed on developing the structure/function relationship of FBPase and ACL inhibitor for glucose/lipid metabolism regulation. In addition, a number of studies are underway exploring the mechanisms underlying and extensive pharmacological characteristics of novel TCM Ramulus Mori (Sangzhi) alkaloid tablets (SZ-A). Recently, she has published 9 research papers as the first /corresponding authors, has been authorized 6 patents and participated in the compilation of 4 monographs.
1. Ramulus mori (sangzhi) alkaloids (sz-a) ameliorate glucose metabolism accompanied by the modulation of gut microbiota and ileal inflammatory damage in type 2 diabetic kkay mice. Frontiers in Pharmacology. 2021.12:642400.
2. Combination of bis (α -furancarboxylato) oxovanadium (IV) and metformin improves hepatic steatosis through downregulating inflammatory pathways in high-fat diet-induced obese C57BL/6J mice. Basic Clin Pharmacol Toxicol. 2021;00:1–11.
3. The Chinese patent medicine, Jin-tang-ning, ameliorates hyperglycemia through improving β cell function in pre-diabetic KKAy mice. Chinese Journal of Natural Medicines. 2020, 18(11): 827-836.
4. Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis. J Med Chem. 2020. 63(18):10307-10329.
5. Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction. Experimental Cell Research. 2018.371, 205-213.
6. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016.167(4): 973-984.
7. The application of 2-NBDG as a fluorescent tracer for assessing hepatic glucose production in mice during hyperinsulinemic euglycemic clamp. Acta Pharmaceutica Sinica B. 2012, 2(4): 403-410.
8. Long-term fenofibrate treatment impaired glucose-stimulated insulin secretion and upregulated pancreatic NF-kappa B and iNOS expression in monosodium glutamate-induced obese rats: Is that a latent disadvantage? Journal of Translational Medicine. 2011. 9:176.2.
9. Discovery of novel indole derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Eur J Med Chem. 2015. 90:394-405.
