LIU Ailin
Principal Investigator
Liu Ailin studied at Macau University for Ph.D. in 2005-2009; at Nankai University for master’s degree in 1992-1995; at Xiamen University for bachelor's degree in 1985-1989. She visited Purdue University in from 2018 to 2019. She has been working at the Institute of Materia Medica, Chinese Academy of Medical Sciences since 1995.
She mainly engages in discovery of drugs for neurodegenerative diseases, anti-infection disease and their mechanism of action, as well as pharmacoinformatics research. Liu has taken charge of more than 20 national projects and participated in more than 30 national projects. Based on these projects, more than 100 research papers have been published, more than 20 professional books have been compiled, and more than 40 patents have been applied for.
1. Identification of multi-target anti-AD chemical constituents from traditional Chinese medicine formulae by integrating virtual screening and in vitro validation. Front. Pharmacol. , 2021, 12:709607. doi: 10.3389/fphar.2021.709607.
2. Design, synthesis, and bioassay of 4-thiazolinone derivatives as influenza neuraminidase inhibitors. European Journal of Medicinal Chemistry . 2021, 213:113161.
3. Discovery of multitarget-directed ligands against influenza a virus from compound Yizhihao through a predictive system for compound-protein interactions. Front Cell Infect Microbiol . 2020, 10:16. doi: 10.3389/fcimb.2020.00016.
4. DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss. Acta Pharmacol Sin. 2020, 41(5):599-611.
5. DL0410 ameliorates cognitive disorder in SAMP8 mice by promoting mitochondrial dynamics and the NMDAR-CREB-BDNF pathway. Acta Pharmacol Sin . 2020 Aug 31. doi:10.1038/s41401-020-00506-2.
6. DL0410 attenuates oxidative stress and neuroinflammation via BDNF/TrkB/ERK/CREB and Nrf2/HO-1 activation. Int Immunopharmacol. 2020 Jul 6;86:106729. doi: 10.1016/j.intimp.2020.106729.
7. Synthesis of chalcone derivatives containing furan or/and pyran ring as neuraminidase inhibitors. Chem Res Chinese Universities , 2019, 35(3):395-402.
8. Pharmacokinetics, excretion and metabolites analysis of DL0410, a dual‑acting cholinesterase inhibitor and histamine‑3 receptor antagonist. Mol Med Rep. 2019, 20: 1103-1112.
9. Identification of estrogen receptor α antagonists from natural products By virtual screening approaches. Oxid Med Cell Longev . 2018, 2018: 6040149. doi:10.1155/2018/6040149.
10. Anti-influenza effect and action mechanisms of the chemical constituent gallocatechin-7-gallate from Pithecellobium clypearia Benth. Acta Pharmacol Sin. 2018, 39(12):1913-1922.
11. Screening of neuraminidase inhibitory activities of some medicinal plants traditionally used in Lingnan Chinese medicines. BMC Complement Altern Med. 2018, 18(1):102. doi: 10.1186/s12906-018-2173-1.
12. Screening of neuraminidase inhibitory activities of some medicinal plants traditionally used in Lingnan Chinese medicines. BMC Complementary and Alternative Medicine , 2018, 18:102. https://doi.org/10.1186/ s12906-018-2173-1.
13. Screening of cytochrome P450 3A4 inhibitors via in silico and in vitro approaches. RSC Adv , 2018, 8, 34783-34792.
14. Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer's Disease. Chinese Journal of Natural Medicines , 2018, 16(1): 0053-0062.
15. Competing endogenous RNA and co-expression network analysis for identification of potential biomarkers and therapeutics in association with metastasis risk and progression of prostate cancer. Oxid Med Cell Longev. 2019, 2019:8265958.
16. Network pharmacology‑based study of the active constituents of Chinese medicinal formulae for antitumor mechanism. World J Tradit Chin Med , 2018, 4(2):43-53.
17. Discovery of VEGFR2 inhibitors by integrating naıve Bayesian classification, molecular docking and drug screening approaches. RSC Advances , 2018, 8: 5286- 5297.
18. DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice. Molecules . 2017, 22(3), 410. pii: E410.
19. Multi-protection of DL0410 in ameliorating cognitive defects in D-galactose induced aging mice. Front Aging Neurosci. 2017, 9:409. doi: 10.3389/fnagi.2017.00409.
20. AlzhCPI: A knowledge base for predicting chemical-protein interactions towards Alzheimer's disease. PLoS One. 2017 May 25;12(5):e0178347. doi: 10.1371/journal.pone.0178347. eCollection 2017.
21. Pharmacokinetic study of gallocatechin-7-gallate from Pithecellobiumclypearia Benth. in rats. Acta Pharmaceutica Sinica B , 2016, 6(1): 64-70.
22. Drug discovery of host CLK1 inhibitors for influenza treatment. Molecules , 2015, 20, 19735–19747.
1. Experimental Pharmacology (2nd Edition) (Chinese). Liu A. and Du G. Edit by Du G. Beijing: Higher Education Press ，2020. Pages 168-183, Print ISBN: 978-7-04-054780-1.
2. The way to drug innovation -- review of the implementation of "1035 project" (Chinese). Liu A. etc. Edited by Chen C and Chen K. Beijing: Higher Education Press ，2019. Pages 136-152, ISBN: 978-7-04-052199-3.
3. Review on the ancient and modern research on "poison" of Traditional Chinese medicine (Chinese). Liu A. Edited by Du G. Beijing: China Pharmaceutical Science and Technology Publishing House ，2019. Pages 148-152, 181-187, 213-217, 244-249, ISBN: 978-7-5214-0668-9.
4. Natural Small Molecule Drugs from Plants (Chinese). Liu A. Edited by Du G. Beijing: People's Health Publishing House . 2018. Pages 84-86, 93-99, 180-182, 240-243, 249-251,. ISBN: 9787117248709.
5. Natural Small Molecule Drugs from Plants. Liu A. etc. Edited by Du G. People's Medical Publishing House. Springer , 2018. Pages 259-264, 271-276, 319-324, 379-384, 491-496, 569-574.
6. Dietary Phytochemicals and Microbes. Chaper 3 Antiviral Properties of Phytochemicals. Liu Ailin. Edited by Amlan KP. Springer sciences, Business Media Dordrecht , 2012. Pages 33-126. ISBN: 978-94-007-3925-3.
1. In 2018, the third prize of Chinese medical science and technology award, China.
2. In 2011, the third prize of Chinese medical science and technology award, China.
3. In 2009, the second prize of Beijing Science and technology award, China.
4. In 2002, the second prize of Beijing Science and technology award, China.
5. In 2002, the third prize of Chinese medical science and technology award, China.
