LI Shuai
Principal Investigator
Education
7/ 2001, Chinese Materia Medica, Beijing University of Chinese Medicine
Work experience
2003 –present: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences. Tutor for graduate and PI in 2006, professor in 2010.
2001- 2003: Postdoctoral researcher, Institute of Materia Medica, Peking Union Medical College.
1999-2000: Visiting Scholar, Natural Medicine and Phytochemistry, Meiji Pharmaceutical University, Japan.
1997-2001: Assistant, Lecturer, at the department of Phytochemistry, School of Pharmacy, Heilongjiang University of Chinese Medicine.
Research fields
The main research fields are to reveal chemical constituents from Traditional Chinese Medicine, on the basis of organic chemistry and analytic chemistry, by extracting, separating the substance and elucidating the structures;
To discovery biological active substances through animals and cells screening, using a wide range of in vitro and in vivo screening tests.
1. Hepatoprotective glucosyloxybenzyl 2-hydroxy-2-isobutylsuccinates from Pleione yunnanensis . J. Nat. Prod, 2021, 84(3), 738-749.
2. Phenanthrene, 9,10-dihydrophenanthrene and bibenzyl enantiomers from Bletilla striata with their antineuroinflammatory and cytotoxic activities. Phytochemistry , 2021,182,112609.
3. New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity. Chin J Nat Med, 2021, 19(5): 376-384.
4. New seco-dibenzocyclooctadiene lignans with nitric oxide production inhibitory activity from the roots of Kadsura longipedunculata . Chin Chem Lett , 2020, 31 (2): 423-426.
5. Sesquiterpenoids, phenolic and lignan glycosides from the roots and rhizomes of Clematis hexapetala Pall. and their bioactivities. Bioorg Chem , 2020, 104: 104312.
6. Hepatoprotective lignans and triterpenoids from the roots of Kadsura longipedunculata . Fitoterapia , 2020, 142: Article 104487.
7. Two new phenanthrenequinones with cytotoxic activity from the tubers of Pleione bulbocodioides . Phytochemistry Letters , 2020, 35, 6-9.
8. Enantiotopic bi (9,10-dihydro) phenanthrene and phenanthrene/bibenzyl dimers with cytotoxic activity from the pseudobulbs of Pleione bulbocodioides . Fitoterapia , 2019, 138: article 104313.
9. Hepatoprotective Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata . J Nat Prod , 2019, 82(10):2842-2851.
10. Phenanthrenequinone enantiomers with cytotoxic activities from the tubers of Pleione bulbocodioides . Org Biomol Chem , 2019, 17(3), 567-572.
11. Structural characterization and immunological activity of polysaccharides from the tuber of Bletilla striata . Int J Biol Macromol , 2019, 122(2): 628-635.
12. Hepatoprotective activity of glucosyloxybenzyl succinate derivatives from the pseudobulbs of Pleione bulbocodioides . Phytochemistry , 2019,157, 71-81.
13. Computationally assisted assignment of the Kadsuraols, a class of chemopreventive agents for the control of liver cancer. Organic Letters , 2018, 20(18): 5559-5563.
14. Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata . J Nat Prod , 2018, 81(4):846-857.
15. Triterpenoids from the Leaves of Ilex chinensis . Phytochemistry , 2018,148, 113-121.
16. New Triterpenoid saponins from the Leaves of Ilex chinensis . Fitoterapia , 2018, 131:134-140.
17. New dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus . J Asian Nat Prod Res , 2018, 20(11): 1019-1027.
18. Assignment of the absolute configuration of hepatoprotective highly oxygenated triterpenoids using X-ray, ECD, NMR J -based configurational analysis and HSQC overlay experiments. BBA-GEN SUBJECTS , 2017, 1861(12): 3089-3095.
19. Tamarixinin A Alleviates Joint Destruction of Rheumatoid Arthritis by Blockade of MAPK and NF-kB Activation. Frontiers in Pharmacology , 2017, 8, article 538.
20. Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-type Nortriterpenoid using X-Ray Diffraction. Molecules , 2017, 22,65.
21. Anti-inflammatory Hydrolyzable Tannins from Myricaria bracteata . J Nat Prod , 2015, 78 (5): 1015-1025.
22. New triterpenoid saponins from the leaves of Cyclocarya paliurus . Chin Chem Lett , 2015, 26(5): 585-589.
23. New Triterpenoid Saponins from the aerial parts of Comastoma pedunculatum . J Asian Nat Prod Res , 2015, 17(3): 239-247.
24. Hepatoprotective Saikosaponin homologs from Comastoma pedunculatum . Planta Medica , 2014, 80(17), 1647-1656.
1. The Chemistry of Chinese edible and medicinal fugus. Editorial board: Li Shuai. Shanghai Science and Technology Literature Press, Print ISBN: 978-7-5439-6915-5.
2. The Research of Natural Medicinal Chemistry. Editorial board: Li Shuai. The Peking Union Medical College Press, Print ISBN: 7-81072-790-7/R. 783.
2010, Heilongjiang Province People's Government, Natural Science Prize, The First Prize.
