LI Pingping
Principal Investigator
Education and work background
2015-present: Professor, the Institute of Materia Medica, CAMS & PUMC
2013-2015: Assistant adjunct professor, the Department of Medicine, University of California, San Diego (UCSD)
2011-2013: Assistant project scientist at UCSD
2006-2011: Postdoc at UCSD
2001-2006: Ph.D. at CAMS & PUMC
Professor Li has been dedicated to studying the pathogenesis of type 2 diabetes for more than 19 years and made several findings in regard to the critical role of immune cells and identification of therapeutic targets in inflammation, insulin resistance and diabetes. In total she has published more than 50 papers and filed 9 Chinese patent applications. As first or corresponding author, Professor Li has published a number of research papers in several preeminent peer-reviewed journals including Cell (3 papers), Nat Med, Cell Metab and PNAS. Her studies have gained considerable attention in the research area and have been cited more than 5000 times by other researchers (as of March 2021).
1. Negative Association between Caloric Intake and Estimated Glomerular Filtration Rate in a Chinese Population: Mediation Models Involving Mitochondrial Function. Gerontology. 2020;66(5):439-446.
2. Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction. Oxid Med Cell Longev. 2020:5384909.
3. Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population. Oxid Med Cell Longev. 2020:9256107.
4. Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity. Cell Reports. 2020; 30: 1835–1847.
5. Targeting Degradation of the Transcription Factor C/EBPbeta Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages. Immunity. 2019; 51, 522-534 e527.
6. Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells. Cell Res. 2019; 29, 516-532.
7. TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription. Nat Commun. 2019; 16;10(1):5720.
8. Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function. J Clin Invest. 2018; 128, 1458-1470.
9. 1,25-Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation. Acta Pharmaceutica Sinica B. 2018; 8(2):178-187.
10. Inflammation and insulin resistance: New targets encourage new thinking: Galectin-3 and LTB4 are pro-inflammatory molecules that can be targeted to restore insulin sensitivity. Bioessays. 2017; 39 (9) PMID: 28752547
11. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell. 2017.
12. Regulation of immune-related diseases by multiple factors: a meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology. Acta Pharmaceutica Sinica B. 2017; 7(4):532-540.
13. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017; 127, 1019-1030 PMID: 28192375
14. HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage. J Clin Invest. 2017; 127, 1353-1369 PMID:28287402
15. Hematopoietic-derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016; 167(4):973-984.e12 PMID: 27814523
16. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell reports. 2016; 14, 255-268. PMID: 26748707
17. The role of dietary fat in obesity-induced insulin resistance. Am J Physiol Endocrinol Metab. 2016;311(6):E989-E97. PMID: 27802965
18. LTB4promotes insulin resistance in obese mice by acting on macrophages, hepatocytesand myocytes. Nat Med. 2015; 21(3): 239-47. PMID: 25706874.
19. FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance. Scientific reports. 2015; 5, 11382. PMID: 26153793
20. Adipocyte SIRT1 knockout promotes PPARgamma activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Molecular metabolism. 2015; 4, 378-391. PMID: 25973386
21. Characterization of a novel glucokinase activator in rat and mouse models. PloS one. 2014; 9, e88431. PMID: 24533087
22. NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids. Cell 2013; 155, 200-214. (* co-first author) PMID: 24074869
23. Neuronal sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. Journal of biological chemistry. 2013; 288, 10722-10735. PMID: 23457303
24. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nature medicine. 2013;19, 313-321. PMID: 23396211
25. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A. 2012; 109(15):5838-43. PMID: 22460790
26. Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell. 2011;147:815-826. PMID: 22078880
27. Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem. 2010;285:15333-15345. PMID: 20308074
28. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol. 2010;24:1413-1422. PMID: 20444886
1. 2016, Outstanding Youth of the National Natural Science Foundation of China, Li Pingping
2. 2017, Qiushi outstanding young scientist, Li Pingping
3. 2018, Beijing Outstanding Young Scientist, Li Pingping
4. 2020, The seventh "Shulan medical award", Li Pingping
