LIN Yuan
Dr. Lin Yuan has been engaged in the drug discovery and molecular mechanism studies of anti-infectious disease. Her research covers drug discovery of anti-tuberculosis, anti-gram-negative bacteria and anti-virus agents. She has published over 15 English articles and 3 patents. Some researches have been published on the main journals of anti-infectious disease worldwide, such as AAC, JAC, IJAA and PNAS. She has received granting funds from NSFC, MOST and CAMS/PUMC. Her outstanding research in anti-infectious drug discovery brought me the "Beijing Nova Star (2017)" and "Young Medical Scientist in CAMS/PUMC (2018)" awards.
1. Identification and characterization of Zika virus NS5 methyltransferase inhibitors. Front Cell Infect Microbial. 2021;11: 665379.
2. Repurposing clinical drugs is a promising strategy to discover drugs against zika virus infection. Front. Med. 2021; 15 (3): 404-415.
3. Identification and characterization of Zika virus NS5 RNA-dependent RNA polymerase inhibitors. Int J Antimicrob Agents . 2019; 54 (4): 502-506.
4. Identification of TB-E12 as a novel FtsZ inhibitor with anti-tuberculosis activity. Tuberculosis (Edinb). 2018; 110: 79-85.
5. Identification of AcAP5 as a novel factor Xa inhibitor with both direct and allosteric inhibition. Biochem Biophys Res Commun. 2017; 483(1): 495-501.
6. Identification of an anti-TB compound targeting the tyrosyl-tRNA synthetase. J Antimicrob Chemother. 2015; 70(8): 2287-2294.
7. The antituberculosis antibiotic capreomycin inhibits protein synthesis by disrupting interaction between ribosomal proteins L12 and L10. Antimicrob Agents Chemother. 2014; 58(4): 2038-2044.
8. Identification of anti-tuberculosis agents that target the cell-division protein FtsZ. J Antibiot (Tokyo), 2014; 67(9): 671-676.
9. Identification of antituberculosis agents that target ribosomal protein interactions using a yeast two-hybrid system. Proc Natl Acad Sci USA . 2012; 109(43): 17412-17417.
10. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the hyperthermophilic nucleotidyltransferase TTHA1015 from Thermus thermophilus HB8. Acta Cryst. 2011; F67, 235-237.
1. Berberine. Science Press, Pages 14-22. Print ISBN: 978-7-03-059038-1.
2. Advanced Pharmacology. Science Press, Pages 634-640. Print ISBN 978-7-03-061139-0.
