LIN Mingbao
Lin Mingbao's research focuses on:
1. Inflammatory immunopharmacology and its innovative drug discovery.
2. Research on mechanism and therapeutic target of respiratory diseases (asthma, COPD, etc .) and its innovative drug screening.
3. Immunopathological mechanism and target of aplastic anemia and its drug discovery.
4. Development of multi-component, multi-target TCM and its therapeutic mechanism in chronic and complex diseases.
1. Comparative RNA‐Seq transcriptome analysis on pulmonary inflammation in a mouse model of asthma-COPD overlap syndrome. Frontiers in Cell and Developmental Biology. 2021, doi: 10.3389/fcell.2021.628957.
2. Syk-Targeted, a New 3-Arylbenzofuran Derivative EAPP-2 Blocks Airway Inflammation of Asthma–COPD Overlap in vivo and in vitro. Journal of Inflammation Research. 2021, 14：2173-2185.
3. Brusatol Derivative - 34 Attenuates Allergic Airway Inflammation via Inhibition of the Syk Pathway. Frontiers in Pharmacology. 2021, doi: 10.3389/fphar.2021.587417.
4. Perilla Leaf Extract Attenuates Asthma Airway Inflammation by Blocking the Syk Pathway. Mediators of Inflammation. 2021：6611219.
5. Multiple Components Rapidly Screened from Perilla Leaves Attenuate Asthma Airway Inflammation by Synergistic Targeting on Syk. Journal of Inflammation Research. 2020, 13: 897–911.
6. Hondroprotective and anti-inflammatory effects of amurensin H by regulating TLR4/Syk/NF-κB signals. J Cell Mol Med. 2020, 24:1958–1968.
7. Amurensin H, a derivative from resveratrol, ameliorates lipopolysaccharide / cigarette smoke‐induced airway inflammation by blocking the Syk/NF-κB pathway. Frontiers in Pharmacology. 2019, 10: 1157.
8. Beneficial Effects of Qingzixiaoban Granule on Henoch–Sch¨onlein Purpura Nephritis Mice through Inhibiting Immune Complex Deposition and Th2 Immunodeviation. ECAM. 2019: 3050248.
9. Tulobuterol patch alleviates allergic asthmic inflammation by blockade of Syk and NF-κB activation in mice. Oncotarget. 2018, 9(15): 12154-12163.
10. Tamarixinin A alleviates joint destruction of rheumatoid arthritis by blockade of MAPK and NF-κB activation. Frontiers in Pharmacology. 2017, 8: 538.doi:10.3389/fphar.2017.00538.
11. Anti-inflammatory effect of a resveratrol derivative 3,4,5-trimethoxy-4′,5′-dihydroxytrans-stilbene (WL-09-5) via ROS-mediated NF-κB pathway. Journal of Asian Natural Products Research. 2016, 18(10): 1004-1013.
