LI Li
Dr. Li joined the National Drug Screening Center in Sep. 2009. She carried out research at the Neuroscience Institute in Henry Ford Hospital for one year as a visiting scholar. In recent years, she has received a number of grants., and participated in many research projects. She has published more than 40 papers (over 30 in SCI) in international professional journals such as Circulation Research and Hypertension; applied for 8 national patents (4 authorized); and participated in the publication of 8 books.
Dr. Li is engaged in the research on cardio-cerebrovascular pharmacology, neuropharmacology and new drug discovery. Her research mainly covers:
1. Drug targets confirmation and innovative drug discovery based on histone deacetylase;
2. New drug targets and drug discovery in stroke and multiple sclerosis;
3. Study of the effect and mechanism of active ingredients in traditional Chinese medicine.
1. Xiaoxuming Decoction Regulates Vascular Function by Modulating G Protein-Coupled Receptors: A Molecular Docking Study. BioMed Research International, 2021, 5575443, https://doi.org/10.1155/2021/5575443.
2. Network pharmacology-based analysis of Xiao-Xu-Ming Decoction on the Treatment of Alzheimer's Disease. Front. Pharmacol, 2020, 11:595254.
3. ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke. Int J Mol Sci., 2020, 21(12):E4369.
4. Activation of Transient Receptor Potential Channel Vanilloid 4 by DPP-4 (Dipeptidyl Peptidase-4) Inhibitor Vildagliptin Protects Against Diabetic Endothelial Dysfunction. Hypertension, 2020, 75(1):150-162.
5. Pinocembrin inhibits angiotensin II-induced vasoconstriction via suppression of the increase of [Ca2+]i and ERK1/2 activation through blocking AT1R in the rat aorta. Biochemical and Biophysical Research Communications, 2013, 435(1):69-75.
6. Rho kinase inhibition activity of pinocembrin in rat aortic rings contracted by angiotensin II. Chinese Journal of Natural Medicines, 2013, 11(3):258-263.
7. SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circulation Research, 2011, 108:1180-1189.
8. SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy. Acta Biochim Biophys Sin, 2011, 43: 103–109.
9. Research progress in the applications of histone deacetylase inhibitors in modulating the function of immune cells and autoimmune diseases. Chinese Pharmacological Bulletin, 2020, 36(11):1481-1486.
10. Research progress in the neurorestorative benefits of mesenchymal stem cells-exosomes for the treatment of ischemic stroke. Acta Pharmaceutica Sinica，2020, 55(10): 2306 −2313.
11. Advances in Bone Mesenchymal Stem Cells Treatment to Promote Neurorestorative Effects after Cerebral Ischemia. Chinese Journal of New Drugs，2020, 29(22): 2576 −2579.
12. Network pharmacology study of Xiaoxuming decoction based on vasodilatory and vasoconstrictory related GPCR targets. China Journal of Chinese Materia Medica. 2018, 43(23):4698-4708.
13. Up-regulation of Fas Ligand Expression by Sirtuin 1 in both Flow-restricted Vessels and Serum-stimulated Vascular Smooth Muscle Cells. Chinese Medical Sciences Journal, 2013, 28(2):65-71.
14. Vasorelaxant effect of Rho kinase inhibitor DL0805 on the isolated rat thoracic aortic rings stimulated by angiotensin II and its underlying mechanisms. Chinese Pharmacological Bulletin，2013, 29(10):1355-1359.
15. ERK1/2 and JNK involved in the inhibitory effect of DL0805 on vasoconstriction induced by angiotensin II in the rat aorta. Basic&Clinical Medicine, 2013, 33(6): 699-703.
16. DL0805 inhibits the vasoconstriction induced by angiotensin Ⅱ in a Ca2+-dependent and Ca2+-independent manner in the rat aorta. Journal of Capital Medical University, 2013, 34(3): 398-403.
1. Experimental pharmacology (2nd Edition). Du GH, … and Li L. Higher Education Press. Print ISBN: 978-7-04-054780-1.
2. Natural Small Molecule Drugs from Plants. Du GH, … and Li L. Springer Press. Print ISBN: 978-981-10-8022-7.
3. Review of the ancient and modern researches on the poison of Chinese medicinal materials. Du GH, … and Li L. China Medical Science and Technology Press. Print ISBN: 978-7-5214-0668-9.
4. Natural Small Molecule Drugs from Plants. Du GH, … and Li L. People's Medical Publishing House. Print ISBN: 978-7-117-24870-9.
5. Goodman Gilman Therapeutics Basis of Pharmacology (12th Edition). Du GH, … and Li L. People's Medical Publishing House. Print ISBN: 978-7-117-21968-6/R.21969.
