LI Gang
Education
2009–2012 Peking Union Medical College, Medicinal Chemistry, Ph.D.
2006–2009 Nanchang University, Medicinal Chemistry, M.S.
2002–2006 Anhui University of Technology, Applied Chemistry, B.S.
Professional career
2012–present Department of Synthetic Medicinal Chemistry, Institute of Materia Medica. Assistant Professor, Associate Professor
Research achievements
As an associate professor and master's supervisor of Chinese Academy Medical Sciences & Peking Union Medical College, Li Gang has engaged in the medicinal chemistry, new drug R&D as well as organic synthetic methodology and had contributed to several therapeutical areas of drug-resistant tuberculosis and metabolic diseases. He has been in charge of several national grants. More than 12 domestic and foreign patents have been applied, and among them 4 have been granted.
1. Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities. J. Med. Chem., 2021, 64, 6241–6261. (Supplementary Cover)
2. Identification of novel benzothiopyranones with ester and amide motifs derived from active metabolite as promising leads against Mycobacterium tuberculosis. Eur. J. Med. Chem., 2021, 222, 113603.
3. The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition. Bioorg. Med. Chem. Lett., 2021, 40, 127924.
4. Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction. ACS Omega, 2021, 6, 14655−14663.
5. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur. J. Med. Chem., 2020, 188, 112017.
6. DMAP catalyzed one-pot synthesis of quinazoline-2,4-diones from 2-aminobenzamides and di-tert-butyl dicarbonate. ACS Omega, 2020, 5, 9614−9623.
7. An efficient and concise access to 2-amino-4H-benzothiopyran-4-one derivatives. Beilstein J. Org. Chem., 2019, 15, 703–709.
8. Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones. Eur. J. Med. Chem., 2018, 160, 157-170.
9. Facile and efficient synthesis of quinazoline-2,4(1H,3H)-diones through sequential hydrogenation condensation. Synth. Commun., 2018, 48(10), 1183-1189.
10. Discovery of novel xanthine compounds targeting DPP-IV and GPR119 as anti-diabetic agents. Eur. J. Med. Chem., 2016, 124, 103-116.
11. An improved and efficient synthesis of the antibacterial agent torezolid. Chem. Pharm. Bull., 2015, 63, 143-146.
12. Ti (IV)-catalyzed cascade synthesis of tetrahydrofuro[3,2-d]oxazole from arene-1,4-diones. Org. Biomol. Chem., 2015, 13, 4418-4421.
13. Iron-catalyzed one-pot synthesis of benzimidazoles from 2-nitroanilines and benzylic alcohols. Tetrahedron Lett., 2013, 54, 6934-6936.
