LAN Jiaqi
Education and work background
2001-2005: B.S., Department of Biology, Tsinghua University, Beijing, China
2005-2010: Ph.D., School of Life Sciences, Tsinghua University, Beijing, China
2010-2014: Postdoctoral research associate, Northeastern University, Boston, MA, US
2014-2020: Assistant prfessor, Institute of Materia Medica, CAMS & PUMC
2020-present: Associate professor, Institute of Materia Medica, CAMS & PUMC
Research interest
Discovery, development and mechanistic research of neuropsychiatric medications, including anxiolytics, antidepressants and treatments of neurodegenerative diseases (Alzheimer's disease and amyotrophic lateral sclerosis), oxidative stress, DNA damage and protection in pharmacology and toxicology based on the yeast proteomics assay.
1. ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis. Neurobiology of Disease . 2021, 153: 105315.
2. Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases. Pharmacological Research. 2021, 163: 105240.
3. Evaluation of non-clinical anxiety disorder models. Acta Pharmaceutica Sinica . 2021, 56(4): 949-965.
4. L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer’s disease mouse model and cultured hippocampal neurons. Molecular Neurobiology . 2020, 58(3):1260-1274.
5. The MMP-2/TIMP-2 system in Alzheimer disease. CNS & Neurological Disorders-Drug Targets. 2020, 9(6):402-416.
6. Toxicity of single-walled carbon nanotubes (SWCNTs): effect of lengths, functional groups and electronic structures revealed by a quantitative toxicogenomics assay. Environmental Science: Nano. 2020, 7: 1348-1364.
7. Exploration of nonclinical pharmacodynamics evaluation system of Alzheimer's disease. Acta Pharmaceutica Sinica . 2020, 55(5): 789-805.
8. Genotoxicity Assessment of Drinking Water Disinfection By-products (DBPs) by DNA Damage and Repair Pathway Profiling Analysis. Environmental science & technology . 2018, 52: 6565-6575.
9. A quantitative toxicogenomics assay for high-throughput and mechanistic genotoxicity assessment and screening of environmental pollutants. Environmental science & technology. 2016,50 (6): 3202-3214.
10. Toxicity Assessment of 4-Methyl-1-cyclohexanemethanol and Its Metabolites in Response to a Recent Chemical Spill in West Virginia, USA. Environmental Science & Technology. 2015, 49(10): 6284-6293.
11. Comparative and Mechanistic Genotoxicity Assessment of Nanomaterials via a Quantitative Toxicogenomics Approach Across Multiple Species. Environmental science & technology. 2014, 48(21): 12937-12945.
12. Evaluation of cytotoxic, genotoxic and inflammatory responses of nanoparticles from photocopiers in three human cell lines. Particle and Fibre Toxicology. 2013, 10:42.
13. Enome-wide functional and stress response profiling reveals toxic mechanism and genes required for tolerance to benzo[a]pyrene in S. cerevisiae. Frontiers in genetics. 2012, 3:316.
14. Developmental toxicity of orally administered pineapple leaf extract in rats. Food and Chemical Toxicology . 2011, 49(6): 1455-1463.
15. Effect of brazilein on energy metabolism of cerebral ischemia-reperfusion in mice. Zhongguo Zhong Yao Za Zhi . 2010, 35(18): 2444-2448.
16. Effect of total flavonoids of Radix Scutellariae on TLR2/Nod2 expression in lung after infection of staphylococcus aureus in vivo and in vitro. Chinese Pharmacological Bulletin . 2009, 25 (7): 866-870.
17. Transport behavior of ellagic acid of pomegranate leaf tannins and its correlation with total cholesterol alteration in HepG2 cells. Biomedical Chromatography . 2009, 23(5), 531-536.
18. Determination of brazilein in rat plasma after intravenous administration by HPLC. Biomedical Chromatography . 2008, 22(11), 1201-1205.
19. Cerebral Ischemia Reperfusion Exacerbates and Pueraria Flavonoids Attenuate Depressive Responses to Stress in Mice. Tsinghua Science and Technology. 2008,13(4): 485-491.
20. Effects of total flavonoids from scutellariae radix on monoamine neurotransmitters in different cerebral nuclei. Chinese Pharmacological Bulletin. 2007, 23(7):855.
21. Transport behavior and efflux of Rg1 in rat pulmonary epithelial cells. Biomedical Chromatography . 2007, 21(6): 635-641.
22. Pharmacokinetic study of p-coumaric acid in mouse after oral administration of extract of Ananas comosus L. leaves. Biomedical Chromatography . 2006, 20(9): 951-955.
Laboratory Animals and Experimental Animal Models. Jiaqi Lan. Edited by Lijun Du and Yu’nan Zhao. China Medical Science Press , Pages 325-364 (chapter 12), 426-459 (chapter 15). Print ISBN: 978-7-5067-4408-9.
