LAI Fangfang
01/2019-08/2019: Harvard Medical School, Training to Teachers- China Program
05/2010-04/2012: Research Associate, University of Toledo, USA.
09/2007-07/2012: Ph.D. of Microbial and Biochemical Pharmacy, Peking Union Medical College, Beijing, China.
09/2003~07/2007: Bachelor of Pharmacy, Zhejiang University, Hangzhou, Zhejiang, China
Lai Fangfang's study is mainly focused on the mechanism of anti-tumor drugs and development of small molecule anti-tumor drugs, including IDO, PD-1/PD-L1, KRAS, CDK8 and PI3K/HDAC. She has published more than 10 SCI papers; participated in the application for more than 20 domestic and foreign patents, and obtained 8 authorized patents. She has presided over or participated in several research projects.
1. Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors. Molecules , 25 (2020).
2. Novel nitric oxide-releasing derivatives of triptolide as antitumor and anti-inflammatory agents: Design, synthesis, biological evaluation, and nitric oxide release studies. Eur J Med Chem , 190 (2020) 112079.
3. Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors. Eur J Med Chem , 188 (2020) 111985.
4. Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases. J Med Chem , 62 (2019) 6992-7014.
5. Chaperone-mediated autophagy degradation of IGF-1Rbeta induced by NVP-AUY922 in pancreatic cancer. Cell Mol Life Sci , 76 (2019) 3433-3447.
6. Sphingosine-1-Phosphate Receptor Subtype 1 (S1P1) Modulator IMMH001 Regulates Adjuvant- and Collagen-Induced Arthritis. Front Pharmacol , 10 (2019) 1085.
7. Rapid Synthesis of gamma-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen. Org Lett , 21 (2019) 2121-2125.
8. Quantitative Evaluation of in Vivo Target Efficacy of Anti-tumor Agents via an Immunofluorescence and EdU Labeling Strategy. Front Pharmacol , 9 (2018) 812.
9. A Morphological identification cell cytotoxicity assay using cytoplasm-localized fluorescent probe (CLFP) to distinguish living and dead cells. Biochem Biophys Res Commun , 482 (2017) 257-263.
10. LXY6090 - a novel manassantin A derivative - limits breast cancer growth through hypoxia-inducible factor-1 inhibition. Onco Targets Ther , 9 (2016) 3829-3840.
11. Identification of a mutant alpha1 Na/K-ATPase that pumps but is defective in signal transduction. J Biol Chem , 288 (2013) 13295-13304.
12. Expression of mutant alpha1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction. J Biol Chem , 288 (2013) 5803-5814.
13. Mycophenolic acid induces ATP-binding cassette transporter A1 (ABCA1) expression through the PPARgamma-LXRalpha-ABCA1 pathway. Biochem Biophys Res Commun , 414 (2011) 779-782.
