KONG Linglei
Kong Linglei graduated with a PhD degree in 2012. Currently he is an associate professor at the Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College. He majors in cardiovascular pharmacology and drug discovery. His research interests include stroke, hemorrhagic transformation after stroke, and screening on compounds or extracts with therapeutic potentials. He has also undertaken a number of national and provincial research projects. Based on his research, Kong has published more than 30 papers as the first or correspondent author. There are 6 patents in the application process.
1. Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites. Acta Pharmacol Sin. 2021.
2. Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats. Int Immunopharmacol. 2021;94:107507.
3. Hypoxia-inducible factor-1: regulatory mechanisms and drug development in stroke. Pharmacol Res. 2021,170:105742.
4. Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway. Acta Pharmacol Sin. 2021;42(3):370-381.
5. Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation. Pharmacological Research. 2021;169:105650.
6. Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers. Int Immunopharmacol. 2021;90:107216.
7. Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate. Front Pharmacol. 2016;7:242.
8. Inhibition of chemokine-like factor 1 improves blood-brain barrier dysfunction in rats following focal cerebral ischemia. Neurosci Lett. 2016;627:192-198.
9. Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice. Sci Rep. 2015;5:11747.
10. Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats. J Neuroinflammation. 2014;11:112.
11. Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect. Neurochem Int. 2014;76:91-98.
2020, Innovation Competition Award, Kong Linglei, Beijing Association for Science and Technology, Beijing, China
