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KONG Jianqiang Principal Investigator
Professor

Department :

Department of Biosynthesis of Natural Products

Platform :

State Key Laboratory of Bioactive Substance and Function of Natural Medicines
NHC Key Laboratory of Biosynthesis of Natural Products

Contact Details

Kong Jianqiang's group
jianqiangk@imm.ac.cn
Brief Introduction

1. The biosynthesis of natural products.

2. Microbial production of natural products through synthetic biology technologies.

Achievements

Papers

1. Diacerein as a promising acyl donor in biosynthetic acetyl-coa and glycosyl esters mediated by a multifunctional maltose O‑acetyltransferase from Escherichia coli. J. Agric. Food Chem, 2021, 69, 6623−6635.

2. Altering the regioselectivity of cytochrome P450 BM3 variant M13 towards genistein through protein engineering and variation of reaction conditions.  ACS Omega, 2020, 5, 49, 32059-32066

3. OcUGT1-catalyzing glycodiversification of steroids through glucosylation and transglucosylation actions. Molecules, 2020, 25, 475.

4. Seven new 1-oxygenated cholestane glycosides from Ornithogalum saundersiae. Journal of Asian Natural Products Research, 2020, 22(3):201-206.

5. Characterization of two flavonol synthases with iron-independent flavanone 3-hydroxylase activity from Ornithogalum caudatum Jacq. BMC Plant Biology, 2019, 19:195.

6. Structure and bioactivity of cholestane glycosides from the bulbs of Ornithogalum saundersiae Baker. Phytochemistry, 2019, 164: 206-214.

7. The enzymatic biosynthesis of acylated steroidal glycosides and their cytotoxic activity. Acta Pharmaceutica Sinica B, 2018, 8(6):981-994.

8. Isolation and characterization of a multifunctional flavonoid glycosyltransferase from Ornithogalum caudatum with glycosidase activity. Scientific Reports, 2018, 8, 5886.

9. OcUGT1-catalyzed glycosylation of testosterone with alternative donor substrates. Process Biochemistry, 2018,73:82-85.

10. Biosynthesis of 7,8-dihydroxyflavone glycosides via OcUGT1-catalyzed glycosylation and transglycosylation. Journal of Asian Natural Products Research, 2018, 20(7):662-674.

11. Steroids hydroxylation catalyzed by the monooxygenase mutant 139-3 from Bacillus megaterium BM3. Acta Pharmaceutica Sinica B, 2017, 7(4):510–516.

Books

Honors & Awards