JI Tengfei
Principal Investigator
Education background
1999-2003: Institute of Materia Medica, CAMS & PUMC, doctor of science
1996-1999: Xinjiang Institute of Chemistry, Chinese Academy of Sciences, master of Science
1992-1996: Department of Chemistry, Xinjiang Normal University, bachelor of science
Work experience
2015-present: Institute of Materia Medica, CAMS & PUMC, professor
2009-2015: Institute of Materia Medica, CAMS & PUMC, associate professor
2012-2013: Xinjiang Uygur Autonomous Region Institute of Medicine, associate professor
2003-2009: Institute of Materia Medica, CAMS & PUMC, assistant professor
Research focus
1) Basic research on pharmacodynamic substances of commonly used traditional Chinese medicine.
2) Research and development of new drugs based on active natural products.
1. Prenylaromadendrane-type diterpenoids from the gum resin of Boswellia sacra Flueck and their cytotoxic effects. Natural Product Research , 2021, https://doi.org/10.1080/ 14786419. 2021.1939331.
2. Structural Revision of Hyperibrin B and Hyperscabrones H and I by Biosynthetic Considerations, NMR, and Chemical Synthesis. Journal of Natural Products , 84(7): 2059-2064 , 2021.
3. Hyperacmosin N , New Acylphloroglucinol Derivative with Complicated Caged Core from Hypericum acmosepalum, Tetrahedron , (94): 132286, 2021.
4. Hyperacmosins K-M, three new polycyclic polyprenylated acylphloroglucinols from Hypericum acmosepalum,， RSC Adv , 11, 21029-21035, 2021.
5. Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway. Acta Pharmaceutica Sinica B , 11(11): 3465-3480, 2021.
6. Large-scale preparative isolation of bergenin standard substance from Saxifraga atrata using polyamide coupled with micro gel chp20p medium pressure chromatography. Journal of Chromatography B , 1170: 122617, 2021.
7. Chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammation. Chem. Commun. , 57(48): 5981-5984, 2021.
8. Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum pseudohenryi. Phytochemistry , 178: 112761, 2021.
9. Hypseudohenrins I−K: three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum pseudohenryi. J Asian Nat Prod Res. , 23(06):536-544, 2021.
10. Hyperterpenoids A and B: Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanie. Chinese Chemical Letters , 32: 2338-2341, 2021.
11. Ten undescribed cembrane-type diterpenoids from the gum resin of Boswellia sacra and their biological activities. Phytochemistry , 177: 112425, 2020.
12. Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum acmosepalum. J Asian Nat Prod Res , 22(6): 521-530, 2020.
13. Hyperacmosins E-G, three new homoadamantane-type polyprenylated acylphloroglucinols from Hypericum acmosepalum. Fitoterapia , 142 :104535, 2020.
14. Preparative isolation of highly polar free radical inhibitor from Floccularia luteovirens using hydrophilic interaction chromatography directed by on-line HPLC-DPPH assay. Journal of Chromatography B , 1142:122043, 2020.
15. 3-O-acetyl-11-keto-β-boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma. Acta Pharmaceutica Sinica B , 10(2):301-312, 2020.
16. Hyperascyrins L−N, rare methylated polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum ascyron. J Asian Nat Prod Res , 21( 5):409-418, 2019.
17. Boscartins L–O: Cembrane-type diterpenoids from the gum resin of Boswellia sacra Flueck. Phytochemistry , 163:126–131, 2019.
18. Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron. J. Nat. Prod. , 81, 2348−2356, 2018.
19. Synthesis and antitumor activities of sinomenine derivatives on rings A and C. J Asian Nat Prod Res , 20 (3): 277-291, 2018.
20. 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. J Exp Clin Canc Res , 37: 132, 2018.
21. Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A - Induced and D-Galactosamine - Induced Liver Injury in Mice. Int. J. Mol. Sci. , 18(3), 587, 2017.
22. Assessment of in vitro cardio- toxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication. Journal of Pharmaceutical and Biomedical Analysis , 137: 84-89, 2017.
23. Synthesis and antitumor activity of novel substituted uracil-1′(N)-acetic acid ester derivatives of 20(S)-camptothecins. Eur J Med Chem , 125: 1235-1246, 2017.
24. Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum scabrum. Bioorg. Med. Chem. Lett. , 27(21): 4932-4936, 2017.
25. Four new prenylated phloroglucinol derivatives from Hypericum scabrum. Tetrahedron Lett ., 57, 2244-2248, 2016.
26. Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum. Fitoterapia , 115: 128-134, 2016.
27. Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum. J. Nat. Prod. , 79 (6):1538–1547, 2016.
28. Effect of Hypericum perforatum L. extract on insulin resistance and lipid metabolic disorder in high-fat-diet induced obese mice. Phytotherapy Research , 29:86-92, 2015.
1. Research and Application of Tianshan Saussurea, Teng-fei Ji, Associate Editor. China Traditional Chinese Medicine Press , 2021.
2. Chinese Edible and Medicinal Fungi Chemistry. Teng-fei Ji, Editorial Board Member. Shanghai Science and Technology Literature Press , 2016.
2017, Second Prize, The 12th Chinese Pharmaceutical Association Science and Technology Award.
