HU Youcai
Principal Investigator
Hu Youcai received his Ph.D. degree in 2008 from Peking Union Medical College, where he studied natural medicinal chemistry with Prof. Yu Shishan. After postdoctoral training in marine natural products (2010-2013) with Prof. John B. MacMillan at UTSW, and fungal natural product biosynthesis (2013-2014) with Prof. Yi Tang at UCLA, he returned to the Institute of Materia Medica, Peking Union Medical College at end of 2014. His research interests focus on genome mining guided discovery and biosynthesis of natural products. He has published more than 60 papers in Journal of American Chemical Society, Angewandte Chemie International Edition, Natural Product Reports, Nature Chemical Biology, etc. He is also engaged as editorial board member of Acta Pharmaceutica Sinica B and Journal of Chinese Medicines, and youth editorial board member of Chinese Chemical Letters, Chinese Journal of Natural Medicines, Green Synthesis & Catalysis and others.
1. Enzymatic Dimerization in the Biosynthetic Pathway of Microbial Natural Products. Natural Product Reports , 2021 (DOI: 10.1039/d0np00063a)
2. Self-Resistance in the Biosynthesis of Fungal Macrolides Involving Cycles of Extracellular Oxidative Activation and Intracellular Reductive Inactivation. Angewandte Chemie International Edition , 2021, 60, 6639–6645.
3. Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products. Acta Pharmaceutica Sinica B , 2021, 11, 572-587.
4. Enzymatic Intermolecular Hetero-Diels−Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes. Journal of the American Chemical Society , 2019, 141, 14052-14056.
5. Complexity and Diversity Generation in the Biosynthesis of Fumiquinazoline-Related Peptidyl Alkaloids. Organic Letters , 2019, 21, 1475-1479.
6. Biosynthesis of Heptacyclic Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide. Journal of the American Chemical Society , 2018, 140, 6991-6997.
7. Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids. Acta Pharmaceutica Sinica B , 2018, 8, 687–697.
8. Activation of an Unconventional Meroterpenoid Gene Cluster in Neosartorya glabra Leads to the Production of New Berkeleyacetals. Acta Pharmaceutica Sinica B , 2018, 8, 478–487.
9. A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angewandte Chemie International Edition , 2017, 56, 4782-4786.
10. Epigenetic Genome Mining of an Endophytic Fungus Leads to the Pleiotropic Biosynthesis of Natural Products. Angewandte Chemie International Edition , 2015, 54, 7592–7596.
1. Natural product biosynthesis: chemical logic and enzymatic machinery. Translated by Hu, Y.C. Edited by Christopher T. Walsh and Yi Tang. Chemical industry press , Print ISBN: 978-7-122-36941-3.
2. Modern research on Chinese herbal medicine. Hu, Y.C. Edited by Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College. China Union Medical University Press , Pages 547-567. Print ISBN: 978-7-81136-354-8/R·354.
3. Phenolic acid chemistry. Yu, S.S., Hu, Y.C., Gao, S., and Liu J. Edited by Dongming Zhang. Chemical industry press , Pages 123-188. Print ISBN: 978-7-122-03736-7.
4. Triterpene chemistry. Ma, S.G., Liu, R., and Hu, Y.C. Edited by Shishan Yu. Chemical industry press , Pages 104-149. Print ISBN: 978-7-122-03331-4.
5. Recent Progress in Medicinal Plants, (Natural phloroglucinols-molecular diversity and bioactivity). Yu, S.S., Hu, Y.C., Wu, X.F., and Liu, J. Edited by V.K. Singh and J.N. Govil. Studium Press , Pages 121-157. Print ISBN: 1-933699-15-9.
1. 2018, Leadership in Scientific Innovation Award, Ministry of Science and Technology of China.
2. 2016, National Excellent Young Scholars Award, National Science Foundation of China.
