HU Kuan
Principal Investigator
Dr. Kuan Hu received his BSc in Radiochemistry from Lanzhou University in 2012. He obtained a Ph.D. in Chemical Genomics in Prof. Zi-gang Li’s lab at Peking University in 2017. His doctoral research was focused on developing peptide stabilization methodologies and their applications in PPI modulators. Prior to joining the National Institutes for Quantum Science and Technolog (QST), he was an assistant professor of Prof. Zhou Li’s group at the Beijing Institute of Nanoenergy and Nanosystems of Chinese Academy of Sciences. He carried out his postdoctoral research in Prof. Ming-Rong Zhang’s team at QST (2018.04-2021.03). In April 2021, he was promoted to a full-time research fellow in QST. Dr. Hu started his current position in June 2022. His group aims to develop highly valuable radiopharmaceuticals for the diagnosis and treatment of various diseases. In particular, he is interested in peptide and protein bioconjugation methodologies with applications in radiolabeling and molecular imaging. Dr. Hu published up to 70 peer-reviewed papers. Dr. Hu is an awardee of a couple of highly prestigious awards, including the Research Award from the Japanese Society of Nuclear Medicine and the JLCR Young Scientist Award from the International Symposium on Radiopharmaceutical Sciences.
1）Duo Wang#, Chan Feng#, Zeyu Xiao#,*, Cuiqing Huang, Zerong Chen, Weiming Fang, Xiaocong Ma, Xingkai Wang, Liangping Luo*, Kuan Hu*, Wei Tao*. Therapeutic hydrogel for enhanced immunotherapy: A powerful combination of MnO2 nanosheets and vascular disruption. Nano Today , 2022, in production.
2) Dongyuan Wang*, Yuan Tian, Yu Zhang, Xiaona Sun, Yuxuan Wu, Ruping Liu, Fang Zeng, Jingjing Du & Kuan Hu*. An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression. Nanoscale , 2022, 14, 15384-15392.
3) Juan Sun#, Zhenyuan Huangfu#, Jiangtao Yang, Guanglin Wang*, Kuan Hu*, Mingyuan Gao & Zhiyuan Zhong*. Imaging-guided targeted radionuclide tumor therapy: From concept to clinical translation. Advanced Drug Delivery Reviews, 2022, 190, 114538.
4) Zeyu Xiao#, Duo Wang#, Chan Wang#, Zerong Chen, Cuiqing Huang, Yuan Yang, Lin Xie, Lulu Zhang, Lingling Xu, Ming-Rong Zhang*, Kuan Hu*, Zhou Li* & Liangping Luo*. PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy. Materials Today Bio , 2022, 100297.
5) Lingling Zhang#, Kuan Hu#, Tuo Shao, Lu Hou, Shaojuan Zhang, Weijian Ye, Lee Josephson, Jeffrey H. Meyer, Ming-Rong Zhang, Neil Vasdev, Jinghao Wang, Hao Xu, Lu Wang* & Steven H. Liang*. Recent developments on PET radiotracers for TSPO and their applications in neuroimaging. Acta Pharmaceutica Sinica B, 2021, 11, 373-393.
6) Lin Xie#, Kuan Hu#, Yanhong Duo#, Takashi Shimokawa, Katsushi Kumata, Yiding Zhang, Cuiping Jiang, Lulu Zhang, Nobuki Nengaki, Hidekatsu Wakizaka, Yihai Cao* & Ming-Rong Zhang*. Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy. Journal for ImmunoTherapy of Cancer 2021, 9, e002616.
7) Duo Wang#, Jun Zhou#, Weimin Fang, Cuiqing Huang, Zerong Chen, Meng Fan, Ming-Rong Zhang, Zeyu Xiao*, Kuan Hu* & Liangping Luo*. A multifunctional nanotheranostic agent potentiates erlotinib to EGFR wild-type non-small cell lung cancer. Bioactive Materials 2021, 13, 312-323.
8) Tong Li, Xian-Mao Lu, Ming-Rong Zhang, Kuan Hu* & Zhou Li*. Peptide-based nanomaterials: Self-assembly, properties and applications. Bioactive Materials 2021, 11, 268-282.
9) Kuan Hu#, Wenyu Wu#, Lin Xie, Hao Geng, Yiding Zhang, Masayuki Hanyu, Lulu Zhang, Yinghuan Liu, Kotaro Nagatsu, Hisashi Suzuki, Jialin Guo, Yundong Wu*, Zigang Li*, Feng Wang* & Mingrong Zhang*. Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors. Acta Pharmaceutica Sinica B 2021, 12, 1363-1376.
10) Chan Wang#, Kuan Hu#, Chaochao Zhao, Yang Zou, Ying Liu, Xuecheng Qu, Dongjie Jiang, Zhe Li, Ming-Rong Zhang & Zhou Li. Customization of Conductive Elastomer Based on PVA/PEI for Stretchable Sensors. Small 2021, 16, 1904758.
11) Kuan Hu, Zhimin Yang#, Lingling Zhang#, Lin Xie, Lu Wang, Hao Xu, Lee Josephson, Steven H. Liang & Ming-Rong Zhang. Boron agents for neutron capture therapy. Coordination Chemistry Reviews 2020, 405, 213139.
12) Kuan Hu, Wei Xiong, Chengjie Sun, Chan Wang, Jingxu Li, Feng Yin, Yixiang Jiang, Ming-Rong Zhang, Zhou Li*, Xinwei Wang* & Zigang Li*. Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size. CCS Chemistry 2020, 2, 42-51.
13) Kuan Hu, Lin Xie, Yiding Zhang, Masayuki Hanyu, Zhimin Yang, Kotaro Nagatsu, Hisashi Suzuki, Jiang Ouyang, Xiaoyuan Ji, Junjie Wei, Hao Xu, Omid C. Farokhzad, Steven H. Liang*, Lu Wang*, Wei Tao* & Ming-Rong Zhang*. Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy. Nature communications 2020, 11, 2778.
14) Kuan Hu, Lin Xie, Masayuki Hanyu, Yiding Zhang, Lingyun Li, Xiaohui Ma, Kotaro Nagatsu, Hisashi Suzuki, Weizhi Wang* & Ming-Rong Zhang*. Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint. RSC Chemical Biology 2020, 1, 214-224.
14) Wei Xiong#, Kuan Hu#, Zhe Li#, Yixiang Jiang, Zigang Li*, Zhou Li* & Xinwei Wang*. A wearable system based on core-shell structured peptide-Co9S8 supercapacitor and triboelectric nanogenerator. Nano Energy 2019, 66, 104149.
15) Zhe Li#, Kuan Hu#, Mengyan Yang#, Yang Zou#, Jinbin Yang, Min Yu, Huaying Wang, Xuecheng Qu, Puchuan Tan, Chan Wang, Xuechang Zhou* & Zhou Li*. Elastic Cu@PPy sponge for hybrid device with energy conversion and storage. Nano Energy 2019, 58, 852-861.
16) Hu Kuan, Hanyu Masayuki, Lin Xie, Yiding Zhang, Nagatsu Kotaro, Suzuki Hisashi & Ming-Rong Zhang. Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation. Chemical Communications 2019, 55, 4162-4165.
17) Kuan Hu#, Feng Yin#, Ziyuan Zhou#, Chenshan Lian, Yinghuan Liu, Chengjie Sun, Wenjun Li, Jianing Zhang & Zigang Li. Directional assembly of a stapled α-helical peptide. Chemical Communications 2019, 55, 10484-10487.
18) Huaying Wang#, Kuan Hu#, Zhe Li#, Chan Wang, Min Yu, Zigang Li* & Zhou Li*. Black Phosphorus Nanosheets Passivation Using a Tripeptide. Small 2018, 14, 1801701.
19) Chan Wang#, Kuan Hu#, Wenjian Li, Huaying Wang, Hu Li, Yang Zou, Chaochao Zhao, Zhe Li, Min Yu & Puchuan Tan, Zhou Li. Wearable Wire-Shaped Symmetric Supercapacitors Based on Activated Carbon-Coated Graphite Fibers. ACS applied materials & interfaces 2018, 10, 34302-34310.
20) Wenjun Li#, Kuan Hu#, Qingzhou Zhang, Dongyuan Wang, Yue Ma, Zhanfeng Hou, Feng Yin* & Zigang Li*. N terminal N-methylation modulates chiral centre induced helical (CIH) peptides' biophysical properties. Chemical Communications 2018, 54, 1865-1868.
21) Kuan Hu*, Chao Zheng, Miao An, Xiaohui Ma* & Lu Wang*. A peptide-based supercapacitor and its performance improvement via TiO2 coating. Journal of Materials Chemistry A 2018, 6, 8047-8052.
22) Kuan Hu#, Yixiang Jiang#, Wei Xiong, Hu Li, Pei-Yu Zhang, Feng Yin, Qianling Zhang, Hao Geng, Fan Jiang*, Zhou Li*, Xinwei Wang* & Zigang Li*. Tuning peptide self-assembly by an in-tether chiral center. Science Advances 2018, 4, eaar5907.
23) Feng Yin#, Kuan Hu#, Yangzi Chen, Mengying Yu, Dongyuan Wang, Qianqian Wang, Ken-Tye Yong, Fei Lu*, Yongye Liang* & Zigang Li*. SiRNA Delivery with PEGylated Graphene Oxide Nan osheets for Combined Photothermal and Genetherapy for Pancreatic Cancer. Theranostics 2017, 7, 1133-1148.
24) Kuan Hu#, Feng Yin#, Mengyin Yu, Chengjie Sun, Jingxu Li, Yujie Liang, Wenjun Li, Mingsheng Xie, Yuanzhi Lao, Wei Liang* & Zi-gang Li*. In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell. Theranostics 2017, 7, 4566-4576.
25) Kuan Hu#, Chengjie Sun#, Mengying Yu, Wenjun Li, Huacan Lin, Jialin Guo, Yixiang Jiang, Chengxiang Lei & Zigang Li. Dual In-Tether Chiral Centers Modulate Peptide Helicity. Bioconjugate Chemistry 2017, 28, 1537-1543.
26) Kuan Hu#, Chengjie Sun#, Dan Yang, Yujie Wu, Chuan Shi, Longjian Chen, Tao Liao, Jialin Guo, Yinghuan Liu & Zigang Li. A precisely positioned chiral center in an i, i + 7 tether modulates the helicity of the backbone peptide. Chemical Communications 2017, 53, 6728-6731.
27) Kuan Hu#, Chengjie Sun# & Zigang Li. Reversible and Versatile On-Tether Modification of Chiral-Center-Induced Helical Peptides. Bioconjugate Chemistry 2017, 28, 2001-2007.
28) Kuan Hu#, Wenjun Li#, Mengying Yu, Chengjie Sun & Zigang Li. Investigation of Cellular Uptakes of the In-Tether Chiral-Center-Induced Helical Pentapeptides. Bioconjugate Chemistry 2016, 27, 2824-2827.
29) Kuan Hu, Hao Geng, Qingzhou Zhang, Qisong Liu, Mingsheng Xie, Chengjie Sun, Wenjun Li, Huacan Lin, Fan Jiang, Tao Wang*, Yun-Dong Wu* & Zigang Li*. An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide. Angewandte Chemie International Edition 2016, 55, 8013-8017.
