HU Haiyu
Principal Investigator
Education background
9/2004-6/2009 Institute of Chemistry, Chinese Academy of Sciences, Organic Chemistry, PhD
9/2000-7/2004 Beijing Institute of Technology, Environmental Engineering, Bachelor
Work experience
3/2015-present Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, PI
1/2014-2/2015 Helmholtz Centre for Infection Research, Junior PI
9/2010-12/2013 Sanofi Visiting scientist; European Molecular Biology Laboratory, post-doc
7/2009-7/2010 Nagoya University, Molecular Design and Organic Materials Laboratory, post-doc
Research interests
Dr. Hu's research interest mainly focuses on the development of new drugs, which include the development of (1) enzyme-activated smart molecular probes, (2) multi-mode imaging, and (3) targeted drug delivery with small molecules as the delivery platform.
1. An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria. Angewandte Chemie International Edition , 2020, 59: 8512-8516.
2. A Pseudopaline Fluorescent Probe for the Selective Detection of Pseudomonas aeruginosa. CCS Chem . 2020, 2, 2405–2417.
3. Rapid differentiation between bacterial infections and cancer using a near-infrared fluorogenic probe. Chemical Science , 2020, 11(12): 3141-3145.
4. Dual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues. ACS Sensors, 2020, 5(6) 1650-1656.
5. A single component self-assembled thermally activated delayed fluorescence nanoprobe. Chemical Communications , 2020, 56(17) 2550-2553
6. Ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity. Chemical Communications, 2019, 55(35): 5064-5067.
7. Rapid Synthesis of γ Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen. Organic Letters , 2019, 21(7) 2121-2125.
8. Ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity. Chemical Communications , 2019, 55(35) 5064-5067.
9. Gadolinium-Labeled Aminoglycoside and Its Potential Application as a Bacteria-Targeting Magnetic Resonance Imaging Contrast Agent. Analytical Chemistry , 2018, 90(3): 1934-1940.
10. Multivalent Siderophore-DOTAM Conjugates as Theranostics for Imaging and Treatment of Bacterial Infections. Angewandte Chemie International Edition , 2017, 56(28): 8272-82.
2019, Young Investigators Awards, Hai-Yu Hu. Institut Mérieux and Chinese Academy Medical Sciences
