HUANG Wei
In 2008, Huang Wei graduated from the Chinese University of Hong Kong with PhD. He was a research assistant at the School of Medicine, Chinese University of Hong Kong. Currently, he is deputy director of the Department of Pharmaceutics, and has solid foundation and rich experience in drug delivery carriers, novel drug delivery systems and innovative preparations. As the director, he has presided over more than 10 projects. He has carried out pioneering research on gene delivery vector in China, and took the lead in developing chitosan nanoparticles for gene delivery. He has made important research achievements in gene delivery vector, nano drug delivery system and innovative preparations, applied for 18 patents and published more than 50 papers.
1. Effective Oral Delivery of Exenatide-Zn2+ complex through Distal Ileum-Targeted Double Layers Nanocarriers Modified with Deoxycholic Acid and Glycocholic Acid in Diabetes Therapy. Biomaterials , 2021: 120944.
2. Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs. Advanced Drug Delivery Reviews , 2017, 115:82-97.
3. Systemic siRNA delivery with a dual pH-responsive and tumor-targeted nanovector for inhibiting tumor growth and spontaneous metastasis in orthotopic murine model of breast carcinoma. Theranostics , 2017, 7(2):357-376.
4. Anti-tumor effects in mice induced by survivin-targeted siRNA delivered through polysaccharide nanoparticles. Biomaterials , 2013, 34(22):5689-5699.
5. Recent advances in drug delivery systems for targeting cancer stem cells. Acta Pharmaceutica Sinica B, 2021, 11(1):55-70.
6. Enhancing anti-melanoma outcomes in mice using novel chitooligosaccharide nanoparticles loaded with therapeutic survivin-targeted siRNA. European Journal of Pharmaceutical Sciences , 2021, 158: 105641.
7. Improving anti-tumor outcomes for palliative intratumoral injection therapy through lecithin-chitosan nanoparticles loading paclitaxel-cholesterol complex. International Journal of Nanomedicine , 2019, 14:689-705.
8. Improving glioblastoma therapeutic outcomes via doxorubicin-loaded nanomicelles modified with borneol. International Journal of Pharmaceutics , 2019, 567: 118485.
9. Improving anti-tumor outcomes for colorectal cancer therapy through in situ thermosensitive gel loading harmine. American Journal of Translational Research , 2020;12(5):1658-1671.
10. Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties for co-delivering paclitaxel and survivin siRNA to enhance antitumor outcomes. International Journal of Nanomedicine , 2018, 13:2405-2426.
11. siRNA-loaded poly(histidine-arginine)6-modifed chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis. International Journal of Nanomedicine , 2017, 12:3221-3234.
12. Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer. International Journal of Nanomedicine , 2016, 11:5457-5472.
13. Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI. European Journal of Pharmaceutical Sciences , 2016, 82:171-182.
14. Optimization of the process variables of tilianin-loaded composite phospholipid liposomes based on response surface-central composite design and pharmacokinetic study. European Journal of Pharmaceutical Sciences , 2016, 85:123-131.
15. Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading aziditaxel as a novel taxane derivative. Pharmazie , 2017, 72(3):152-160.
16. Development of solid lipid nanoparticles containing total flavonoid extract from Dracocephalum moldavica L. and their therapeutic effect against myocardial ischemia-reperfusion injury in rats. International Journal of Nanomedicine , 2017, 12:3253-3265.
17. Enhancing in vivo bioavailability in beagle bogs of GLM-7 as a novel anti-leukemia drug through a self-emulsifying drug delivery system for oral delivery. Current Drug Delivery , 2016, 13:131-142.
18. Novel ethylcellulose-coated pellets for controlled release of metoprolol succinate without lag phase: characterization, optimization and in vivo evaluation. Drug Development and Industrial Pharmacy , 2015, 41(7):1120-1129.
19. Simultaneous Determination of Six Active Compounds in Yixin Badiranjibuya Granules, a Traditional Chinese Medicine, by RP-HPLC-UV Method. Journal of Analytical Methods in Chemistry , 2015:974039.
20. The influence of the gut microbiota on the bioavailability of oral drugs. Acta Pharmaceutica Sinica B , https://doi.org/10.1016/j.apsb.2020.09.013.
21. Improved Antitumor Outcomes for Colon Cancer Using Nanomicelles Loaded with the Novel Antitumor Agent LA67. International Journal of Nanomedicine , 2020, 15:3563-3576.
22. Anti-tumor outcome evaluation against non-small cell lung cancer in vitro and in vivo using PolyI:C as nucleic acid therapeutic agent. American Journal of Translational Research , 2019, 11(4): 1919-1937.
23. Improving the anti-keloid outcomes through liposomes loading paclitaxel–cholesterol complexes. International Journal of Nanomedicine , 2019,14:1385-1400.
24. Topical application of JAK1/JAK2 inhibitor momelotinib exhibits significant anti-Inflammatory responses in DNCB-induced atopic dermatitis model mice. International Journal of Molecular Sciences , 2018, 19(12), 3973.
25. Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma. Biomaterials , 2014, 35(25):7008-7021.
26. An effective tumor-targeting strategy utilizing hypoxia-sensitive siRNA delivery system for improved anti-tumor outcome. Acta Biomaterialia , 2016, 44:341-354.
27. Chitosan-based nanoparticles for survivin targeted siRNA delivery in breast tumor therapy and preventing its metastasis. International Journal of Nanomedicine , 2016,11:4931-4945.
28. PEGylation of Lumbrokinase improves pharmacokinetic profile and enhances anti-thrombotic effect in a rat carotid artery thrombosis model. Molecular Medicine Reports, 2017, 16(4):4909-4914.
29. High gene delivery efficiency of alkylated low-molecular-weight polyethylenimine through gemini surfactant-like effect. International Journal of Nanomedicine , 2014, 9:3567-3581.
30. Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model. BMC Cancer , 2014, 14:329.
31. A novel monomethoxy polyethylene glycol-polylactic acid polymeric micelles with higher loading capacity for docetaxel and well-reconstitution characteristics and its anti-metastasis study. Chemical & Pharmaceutical Bulletin , 2012, 60(9):1146-1154.
1. 2013, the third prize of the 11th National Medical and Health Youth Science and Technology Forum, Science And Technology Education Division Of The National Health And Family Planning Commission, Chinese Academy of Medical Sciences, China.
2. 2012, the sixth excellent research paper of Acta Pharmaceutica Sinica, Editorial department of Acta Pharmaceutica Sinica, China.
