HE Jiuming
Principal Investigator
Dr. He recent research mainly focused on the disciplines of mass spectrometry (MS) and medicine with an emphasis on the ambient MS ionization and imaging method and their application in molecular mapping for cancer research, neuroscience, drug research and development. His group in PUMC proposed and developed Air Flow-Assisted Desorption Ionization (AFADESI)-Mass Spectrometry Imaging (MSI), data processing software MassImager and spatially-resolved metabolomics method. AFADESI-MSI system, integrating device, software and application method, has been developed as a powerful tool for small molecular mapping in bio-tissue. His group have demonstrated that MSI based metabolomics is emerging and promising for cancer metabolism research, pharmacokinetics and pharmacodynamics research. He has pioneered a novel paradigm for the high throughput discovery of cancer-related metabolic alternation from metabolites to enzymes. He designed a metabolite-Taxol conjugate prodrug for the tumor targeted-therapy which is developing as a high efficiency and low toxicity antitumor drug.
1. Mapping metabolic networks in the brain by using ambient mass spectrometry imaging and metabolomics. Analytical Chemistry , 2021，93, 6746−6754.
2. Evaluation of the tumor-targeting efficiency and intratumor heterogeneity of anticancer drugs using quantitative mass spectrometry imaging. Theranostics, 2020; 10(6): 2621-2630.
3. Accurate classification of non-small cell lung cancer (NSCLC) pathology and mapping of EGFR mutation spatial distribution by ambient mass spectrometry imaging. Front. Oncol., 2019, 9: 804.
4. A graphical data processing pipeline for mass spectrometry imaging-based spatially resolved metabolomics on tumor heterogeneity. Analytica chimica acta, 2019. 1077, 183-190.
5. Virtual Calibration Quantitative Mass Spectrometry Imaging for Accurately Mapping Analytes Across Heterogenous Bio-tissue. Anal. Chem., 2019，91, 4, 2838-2846.
6. Spatially resolved metabolomics to discover tumor-associated metabolic alterations, Proceedings of the National Academy of Sciences of the United States of America. PNAS，2019，116 (1)，52-57.
7. A high-performance bio-tissue imaging method using air flow-assisted desorption electrospray ionization coupled with a high-resolution mass spectrometer. Chinese Chemical Letters, 2019, 30, 461–464.
8. A Sensitive and Wide cCoverage Ambient Mass Spectrometry Imaging Method for Functional Metabolites Based Molecular Histology. Advanced Science，2018, 5, 1800250.
9. MassImager: A software for interactive and in-depth analysis of mass spectrometry imaging data. Analytica Chimica Acta，2018，1015，50-57.
10. In situ Hydrogel Conditioning of Tissue Samples to Enhance the Drug’s Sensitivity in Ambient Mass Spectrometry Imaging. Analytical Chemistry, 2017, 89 (12), 6318–6323.
