Educational background
09/2005-07/2010, Institute of Materia Medica, CAMS & PUMC, Ph.D. in medicinal chemistry
09/2001-07/2005, Shenyang Pharmaceutical University, B.S. in traditional Chinese pharmacology
Work experience
10/2016 - present, Associated research fellow, Institute of Materia Medica, CAMS
09/2016-08/2010, Assistant research fellow, Institute of Materia Medica, CAMS
Research interests
1. Discovery of bioactive natural products from the microorganisms, such as marine microorganisms, or medicinal fungi, etc.
2. Synthetic biology of scarce and natural medicines, recombinant enzymes of biocatalysis.
1. Fed-batch high-cell-density fermentation strategies for Pichia pastoris growth and production. Crit. Rev. Biotechnol., 2019, 39(2): 258-271.
2. Tetrocarcin Q, a New Spirotetronate with a Unique Glycosyl Group from a Marine-Derived Actinomycete Micromonospora carbonacea LS276. Marine Drugs, 2018, 16, 74.
3. Chrysoxanthones A–C, Three New Xanthone–Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone Deacetylase Inhibitor. Marine Drugs, 2018, 16, 357.
4. Improving 10-deacetylbaccatin III-10-β-Oacetyltransferase catalytic fitness for Taxol production. Nature Communications, 2017, 8: 15544.
5. Scaling-up fermentation of Pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement. Scientific Reports, 2016, 6: 18439.
6. A new analogue of echinomycin and a new cyclic dipeptide from a marine-derived Streptomyces sp. LS298. Marine Drugs, 2015, 13(11): 6947-6961.
7. Two new monoterpenoid α-pyrones from a fungus Nectria sp. HLS206 associated with the marine sponge Gelliodes carnosa. J Asian Nat Prod Res., 2015, 17(6): 633-637.
8. Microbial transformation of oleanolic acid by Trichothecium roseum. J Asian Nat Prod Res., 2014, 16(4): 383-386.
9. Two new isoflavone glycosides from the vine stem of Millettia dielsiana. J Asian Nat Prod Res., 2014, 16 (2): 181.
10. A novel 3-arylcoumarin and three new 2-arylbenzofurans from Mucuna birdwoodiana. Chemical & Pharmaceutical Bulletin, 2010, 41 (29): 254-256.