GAO Zhonggao
Principal Investigator
Gao Zhonggao, Ph.D., was introduced by the Institute of Materia Medica as an international high-end talent in 2008 and served as a professor and doctoral supervisor. He recruited the first doctoral student of pharmaceutics in the history of Peking Union Medical College. Many doctoral graduates were awarded the honor of "Beijing excellent graduates". He has undertaken a number of national and international projects. More than 80 papers have been published, including more than 60 SCI papers, and many papers have been published in famous journals, such as ADDR, Journal of the National Cancer Institute, Nano Letters, PNAS, Biomaterials, Small, JCR, Acta Biomaterialia, etc. At present, he is also the editorial board member of Acta Pharmaceutica Sinica (Chinese and English Edition) and has long been the reviewer of famous international journals.
1. Effective Oral Delivery of Exenatide-Zn2+ complex through Distal Ileum-Targeted Double Layers Nanocarriers Modified with Deoxycholic Acid and Glycocholic Acid in Diabetes Therapy. Biomaterials, 2021: 120944.
2. Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs. Advanced Drug Delivery Reviews, 2017, 115:82-97.
3. Systemic siRNA Delivery With a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma. Theranostics, 2017, 7(2):357-376.
4. Polydatin protects the respiratory system from PM2.5 exposure. Scientific Reports, 2017, 7:40030.
5. siRNA-loaded poly(histidine-arginine)6-modifed chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis. International Journal of Nanomedicine , 2017, 12:3221–3234.
6. An effective tumor-targeting strategy utilizing hypoxia-sensitive siRNA delivery system for improved anti-tumor outcome. Acta Biomaterialia , 2016, 44:341-354.
7. Chitosan-based nanoparticles for survivin targeted siRNA delivery in breast tumor therapy and preventing its metastasis. International Journal of Nanomedicine , 2016,11:4931-4945.
8. Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and inhibitory effect on tumor growth and metastasis against clinically associated 4T1 murine breast cancer. International Journal of Nanomedicine , 2016, 11:5457-5472.
9. Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI. European Journal of Pharmaceutical Sciences , 2016, 82:171–182.
10. Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading Aziditaxel as a novel taxane derivative. Pharmazie , 2017, 72(3):152-160.
11. Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment. Acta Pharmaceutica Sinica B , 2015, 5(3):169-175.
12. Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma. Biomaterials , 2014, 35(25):7008-7021.
13. Efficient gene delivery of alkylated low molecular weight polyethylenimine through gemini surfactant-like effect. International Journal of Nanomedicine , 2014, 9(1):3567-3581.
14. Anti-tumor effects in mice induced by Survivin-targeted siRNA delivered through polysaccharide nanoparticles. Biomaterials , 2013, 34(22):5689-5699.
15. Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model. BMC Cancer , 2014, 14:329.
16. Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo. Acta Pharmaceutica Sinica B , 2013, 3(2):123-129.
17. A Novel Monomethoxy Polyethylene Glycol-Polylactic Acid Polymeric Micelles with Higher Loading Capacity for Docetaxel and Well-Reconstitution Characteristics and Its Anti-metastasis Study. Chem Pharm Bull , 2012, 60(9):1146-1154.
18. Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery. Chinese Chemical Letters , 2011, 22(6):749-752.
19. Prevention of Metastasis in a 4T1 Murine Breast Cancer Model by Doxorubicin Carried by Folate Conjugated pH Sensitive Polymeric Micelles. Journal of Controlled Release , 2011, 152:84-89.
20. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions. Journal of Controlled Release , 2011,153 (1):4-15.
21. In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer. Molecular Pharmaceutics, 2009, 6(5):1353-1362.
22. DNA Loaded Nano particle Reduced Binding and Preferential Extravasation from Tumor Blood Vessel. International Journal of Pharmaceutics , 2009, 369(1-2):155-61.
23. Doxorubicin-loaded Polymeric Micelle Overcomes Multidrug Resistance of Cancer by Double-Targeting Folate Receptor and Early Endosomal pH. Small , 2008, 4 (11):2043-2050.
24. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. Journal of the National Cancer Institute , 2007, 99(14):1095-1106.
25. Immunomicelles-targeted Pharmaceutical Carriers for Poorly Soluble Drugs. Proc. Natl. Acad. Sci., 2003, 100 (10):6039-44.
26. Diacyllipid-polymer micelles as nanocarriers for poorly soluble anticancer drugs. Nano Letters , 2002, 2(9):979-982.
27. Polyethylene glycol-diacyllipid micelles demonstrate increased accumulation in subcutaneous tumors in mice. Pharmaceutical Research, 2002, 19 (10):1422-1427.
28. Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance. Journal of Controlled Release, 2008, 129(3):228-236.
29. Recent progress in tumor pH targeting Nanotechnology. Journal of Controlled Release, 2008, 132(3):164-70.
30. Multifunctional Nanparticles for Targeting Cancer Therapy. J Nanosci Nanotechno, 2010, 10 (11):7743-774.
31. Thermal Reversible Microemulsion System for Poorly Water Soluble YH439 for Oral Delivery. Chemical & Pharmaceutical Bulletin, 2010, 58(1):11-15.
32. Combined Tumor Chemotherapy by Micellar-Encapsulated Drug and Ultrasound. Journal of Controlled Release, 2005,102 (1):203-222.
33. Ultrasound-Triggered Targeting of Micellar-Encapsulated Drugs to Ovarian Carcinoma Tumors In Vivo. Molecular Pharmaceutics, 2004, 1(4):317-330.
1. Microemulsions-An Introduction to Properties and Applications. Zhonggao Gao, Edited by Reza Najjar. InTech Press , Chapter 6: Thermal Revisable Microemulsion for Poorly Water-Soluble Drugs Oral Delivery. Print ISBN:978-953-51-0247-2.
2. Carrier based drug delivery. V.P. Torchilin, A.N. Lukyanov, Z. Gao, J. Wang, and T.S. Levchenko, Edited by Sönke Svenson. Oxford University Press , Chapter 9: Polymeric Micelles as Targetable Pharmaceutical Carriers. Print ISBN:9780841238398.
3. Nanobiomaterials Handbook. Zhonggao Gao, Mingji Jin. Edited by Balaji Sitharaman. CRC Press , Chapter 14, Page 1-16: "Multifuntinonal Nanoparticle for Tumor Targeting Thearpy". Print ISBN: 9781138076525.
1. 2020, "China's highly cited scholars in 2019", Gao Zhonghao, Elsevier, Netherlands.
2. 2019, "China's highly cited scholars in 2018", Gao Zhonghao, Elsevier, Netherlands.
3. 2018, "China's highly cited scholars in 2017", Gao Zhonghao, Elsevier, Netherlands.
4. 2017, "China's highly cited scholar in 2016", Gao Zhonghao, Elsevier, Netherlands.
