GAO Tianle
Dr. Gao has received doctoral training at Karolinska Institutet from 2010 to 2014 in Zsusanna Wiesenfeld-Hallin’s group. During this period, he has discovered that sinomenine, a naturally derived alkaloid has broad spectrum analgesic property. Since then, Dr. Gao’s research has been focused on the discovery of novel analgesics for treatment of chronic pain form natural resources, and the clarification of underlying molecular mechanisms.
1. Kong L#, Rong X#*, Yan P, Qin T, Zhang X, Kang Y, Cheng B, Su W, Gao T, Tie C*. The influence of Hyssopus cuspidatus Boriss extract on lipid mediators metabolism network in asthmatic mice. Front. Pharmacol. 2023; 14:1066643. doi: 10.3389/fphar.2023.1066643.
2. Guo H#, Shen H#, Tang M, Sheng N, Ding X, Lin Y, Zhang J, Jiang J-D, Gao T*, Wang L*, Han Y*. Microbiota-derived short-chain fatty acids mediate the effects of dengzhan shengmai in ameliorating cerebral ischemia via the gut-brain axis. J Ethnopharmacol. 2023; 306:116158. doi: 10.1016/j.jep.2023.116158.
3. Jiang W#, Tang M#, Yang L#, Zhao X#, Gao J#, Jiao Y, Li T, Tie C, Gao T*, Han Y*, Jiang JD*. Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management. Front Pharmacol. 2022;13:851508. doi: 10.3389/fphar.2022.851508.
4. Wang Y, Tong Q, Ma SR, Zhao ZX, Pan LB, Cong L, Han P, Peng R, Yu H, Lin Y, Gao T, Shou JW, Li XY, Zhang XF, Zhang ZW, Fu J, Wen BY, Yu JB, Cao X, Jiang JD. Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota. Signal Transduct Target Ther. 2021; 6(1):77. doi: 10.1038/s41392-020-00456-5. PMID: 33623004.
5. Gao T#, Li T#, Jiang W#, Fan W#, Xu X-J, Zhao X, Yin Z, Guo H, Wang L, Gao J*, Han Y*, Jiang J-D* and Wang D*. Antinociceptive Effects of Sinomenine Combined With Ligustrazine or Paracetamol in Animal Models of Incisional and Inflammatory Pain. Front. Physiol. 2021; 11:523769. doi: 10.3389/fphys.2020.523769.
6. Dondalska A, Rönnberg E, Ma H, Pålsson SA, Magnusdottir E, Gao T, Adam L, Lerner EA, Nilsson G, Lagerström M, Spetz AL. Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by a Single-Stranded Oligonucleotide. Front Immunol. 2020; 11:559589. doi: 10.3389/fimmu.2020.559589.
7. Jiang W#, Fan W#, Gao T#, Li T#, Yin Z, Guo H, Wang L, Han Y*, Jiang J-D. Analgesic Mechanism of Sinomenine against Chronic Pain. Pain Research and Management 2020; 2020:1876862.
8. Ma H#, Gao T#, Jakobsson JET, Weman HM, Xu B, Larhammar D, Lagerström MC*.The Neuropeptide Y Y2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y2 Activation Reduces Histaminergic and IL-31-Induced Itch. J Pharmacol Exp Ther. 2020; 372(1):73-82. DOI:10.1124/jpet.119.262584.
9. Gao T*, Jiao Y, Liu Y, Li T, Wang Z, Wang D*. Protective Effects of Konjac and Inulin Extracts on Type 1 and Type 2 Diabetes. J Diabetes Res. 2019; 2019:3872182. DOI: 10.1155/2019/3872182.
10. Gao T*, Li T, Jiang W, Fan W, Jiang JD. Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissue. Data Brief. 2019; 27:104633. DOI: 10.1016/j.dib.2019.104633.
11. Gao T#, Shi T#, Wiesenfeld-Hallin Z, Li T, Jiang JD*, Xu XJ. Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain. Eur J Pharmacol. 2019; 854:101-108. DOI: 10.1016/j.ejphar.2019.03.061.
12. Fernandez-Zafra T, Gao T, Jurczak A，Sandor K, Hore Z, Agalave NM, Su J, Estelius J, Lampa J, Hokfelt T, Wisenfeld-Hallin Z, Xu X, Denk F，Svensson CI*. Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis. Pain 2019; 160(1): 224-36. DOI:10.1097/j.pain.0000000000001394.
13. Gao T#，Ma H#, Xu B, Bergman J, Larhammar D, Lagerstrom MC*. The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch. Journal of Investigative Dermatology 2018; 138:2405-11. DOI:10.1016/j.jid.2018.05.008.
