BAO Xiuqi
Education & Working Background
09/2008 - present, Department of Pharmacology, Institute of Materia Medica, CAMS and PUMC, Assistant Professor, Associate Professor
09/2005 - 07/2008 Peking Union Medical College, Ph.D.
07/2002 - 08/2005 Institute of Electrical Engineering, Chinses Academy of Sciences, Assistant Professor
09/1999 - 07/2002 Tianjin Medical University, Master degree
09/1994 - 07/1999 Jining Medical college, Bachelor degree
Research Interests
1. Explore the pathogenesis, new targets and new drug development of neuropsychiatric diseases;
2. Research on the mechanisms of inflammation and immune related diseases and develop therapeutic drugs;
3. Study on the mechanisms of gut microbes in the process of various diseases.
1. Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson’s disease treatment. Acta Pharmaceutica Sinica B. Accepted.
2. Autoimmune polyendocrine syndrome induced by immune checkpoint inhibitors: a systematic review. Cancer Immunol Immunother, 2020.
3. CXCR2 antagonism promotes oligodendrocyte precursor cell differentiation and enhances remyelination in a mouse model of multiple sclerosis. Neurobiol Dis, 2020.
4. Novel phloroglucinol derivative Compound 21 protects experimental autoimmune encephalomyelitis rats via inhibiting Th1/Th17 cell infiltration. Brain Behav Immun, 2020.
5. Induction of glial cell line-derived neurotrophic factor by the squamosamide derivative FLZ in astroglia has neuroprotective effects on dopaminergic neurons. Brain Res Bull, 2020 Jan;154:32-42.
6. Discovery of coumarinMannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease. European journal of medicinal chemistry, 2019.
7. Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation. Sci China Life Sci, 2019.
8. Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of 3- Hydroxymorphinan. Sci Rep. 2019 Feb 19;9(1):2247.
9. A Novel Synthetic Derivative of Phloroglucinol Inhibits Neuroinflammatory Responses Through Attenuating Kalirin Signaling Pathway in Murine BV2 Microglial Cells. Mol Neurobiol, 2018.
10. Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway. Redox Biol, 2018.
11. Heat shock protein 70 suppresses neuroinflammation induced by α-synuclein in rat primary astrocytes. Mol Cell Neurosci. 2018;86:58-64.
12. FLZ Attenuates α-Synuclein-Induced Neurotoxicity by Activating Heat Shock Protein 70. Mol Neurobiol, 2017.
13. A Novel Parkinson's Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway. J Med Chem, 2016.
14. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Neuropharmacology, 2013.
