BAI Jian
Bai Jian received his Ph. D. degree in Medicinal Chemistry from Peking Union Medical College in 2011. He pursued his postdoctoral studies at School of Pharmacy, Peking University. In 2014, Dr. Bai joined the faculty at the Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College. His work has focused on Natural Medicine Chemistry and Synthetic Biology.
Major research interests include: (1) Genome mining guided fungal bioactive natural products discovery; (2) Biosynthesis and synthetic biology of bioactive natural products. He has published more than 20 research papers at Angew Chem Int Ed , J Am Chem Soc, Acta Pharm Sin B, Org Lett, etc., some of which have been recommended by "Faculty of 1000".
1. Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products. Acta Pharmaceutica Sinica B , 2021, 11(2): 572-587.
2. Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids. Acta Pharmaceutica Sinica B , 2018, 8, 687-697.
3. A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angewandte Chemie International Edition, 2017, 56, 4782-4786.
4. Amicoumacins from the marine-derived bacterium Bacillus sp. with the inhibition of NO production. Tetrahedron Letters, 2014, 55, 6286-6291.
5. Sesquiterpenes from the roots of Illicium dunnianum. Phytochemistry, 2012, 80, 137-147.
6. Antioxidant phenolic glycosides from the roots of Illicium dunnianum. Carbohydrate Research, 2012, 361, 206-211.
7. Sesquiterpenes and neolignans from the roots of Illicium dunnianum. Journal of Asian Natural Products Research, 2012, 14, 940-949.
8. Self-resistance in the biosynthesis of fungal macrolides involving cycles of extracellular oxidative activation and intracellular reductive inactivation. Angewandte Chemie International Edition, 2021, 60, 6639-6645.
9. Highly oxygenated caryophyllene-type sesquiterpenes from a plant-associated fungus, Pestalotiopsis hainanensis , and their biosynthetic gene cluster. Journal of Natural Products, 2020, 83(11), 3262–3269.
10. Enzymatic Intermolecular Hetero-Diels−Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes. Journal of the American Chemical Society, 2019, 141(36), 14052-14056.
11. Complexity and Diversity Generation in the Biosynthesis of Fumiquinazoline-Related Peptidyl Alkaloids. Organic Letters, 2019, 21 (5), 1475-1479.
12. Activation of an Unconventional Meroterpenoid Gene Cluster in Neosartorya glabra Leads to the Production of New Berkeleyacetals. Acta Pharmaceutica Sinica B, 2018, 8(3), 478-487.
13. Diphenyl Ethers from a Marine-Derived Aspergillus sydowii. Marine Drugs, 2018, 16, 451-461.
