科研队伍

2009年毕业于军事医学科学院毒物药物研究所,获硕士学位;2012年毕业于中国医学科学院药物研究所,获博士学位,同年进入军事医学科学院毒物药物研究所进行博士后研究工作,2015年9月进入国家药物筛选中心工作。2016年9月获聘副研究员;2020年7月取得研究员资格。作为课题负责人或子任务负责人承担国家自然科学基金、北京自然科学基金、中国博士后面上基金、十三五重大新药创制科技重大专项、中国医学科学院医学与健康科技创新工程等项目,以第一作者或通讯作者发表论文30余篇,申请专利6项。担任中国药理学会中药与天然药物药理青年委员会副秘书长,中国民族医药学会药理与毒理学分会理事,中国药理学会补益药药理专业委员会委员,中国中药协会脑病专业委员会委员等。Acta Pharmacologica Sinica、Frontiers in Pharmacology、Translational Stroke Research、中国药理学与毒理学杂志等知名中英文期刊审稿人。

主要从事心脑血管药理学及新药发现方面的工作。研究内容包括:脑缺血及溶栓后出血转化发生的分子机制和药物干预研究;脑缺血相关药物靶点确证及先导化合物的筛选、评价。

1. Linglei Kong, Li Gao, Kexin Wang, Nannan Liu, Chengdi Liu, Guo-Dong Ma, Haiguang Yang, Xuemei Qin, Guanhua Du. Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites. Acta Pharmacol Sin. 2021.
2. Linglei Kong, Yinzhong Ma, Zhiyuan Wang, Nannan Liu, Guodong Ma, Chengdi Liu, Ruili Shi, Guanhua Du. Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats. Int Immunopharmacol. 2021;94:107507.
3. Zirong Pan, Guodong Ma, Linglei Kong#, Guanhua Du#. Hypoxia-inducible factor-1: regulatory mechanisms and drug development in stroke. Pharmacol Res. 2021,170:105742.
4. Chengdi Liu, Nannan Liu, Sen Zhang, Guodong Ma, Haiguang Yang, Linglei Kong#, Guanhua Du#. Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway. Acta Pharmacol Sin. 2021;42(3):370-381.
5. Nannan Liu, Chengdi Liu, Yujiao Yang, Guodong Ma, Guangyi Wei, Shan Liu, Linglei Kong#, Guanhua Du#. Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation. Pharmacological Research. 2021;169:105650.
6. Guodong Ma, Zirong Pan, Linglei Kong#, Guanhua Du#. Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers. Int Immunopharmacol. 2021;90:107216.
7. Linglei Kong, Guolin Shen, Zhiyuan Wang, Xiaomei Zhuang, Weibin Xiao, Mei Yuan, Zehui Gong, Hua Li. Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate. Front Pharmacol. 2016;7:242.
8. Linglei Kong, Zhiyuan Wang, Jinfeng Hu, Yuhe Yuan, Hua Li, Naihong Chen. Inhibition of chemokine-like factor 1 improves blood-brain barrier dysfunction in rats following focal cerebral ischemia. Neurosci Lett. 2016;627:192-198.
9. Linglei Kong, Xiaomei Zhuang, Haiying Yang, Mei Yuan, Liang Xu, Hua Li. Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice. Sci Rep. 2015;5:11747.
10. Linglei Kong, Zhiyuan Wang, Ning Han, Xiaomei Zhuang, Zhenzhen Wang, Hua Li, Nai Hong Chen. Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats. J Neuroinflammation. 2014;11:112.
11. Linglei Kong, Zhiyuan Wang, Jinfeng Hu, Yuhe Yuan, Ning Han, Hua Li, Nai Hong Chen. Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect. Neurochem Int. 2014;76:91-98

1. 《天然小分子药物》,编委,人民卫生出版社,2019年
2. 《中药材【毒】古今研究概评》,编委,中国医药科技出版社,2018年
3. 《Natural Small Molecule Drugs from Plants》,编者,Springer,2019年
4. 《实验药理学》,编者,高等教育出版社,2021年

1. 丹酚酸A在制备抗脑出血药物中的应用,申请号:201811248469.1
2. 消栓通络方有效成分组用于治疗脑出血的用途,申请号:201910164178.2
3. 香草酸在制备抗血小板、抗血栓形成药物中的应用,申请号:201910264389.3
4. 高香草酸在制备抗血小板、抗血栓形成药物中的应用,申请号:201911318695.7
5. 丹酚酸A在制备预防血栓性脑缺血的药物中的应用,申请号:202010589934.9

1.2020年,北京市科学技术协会,创新争先奖