河南中医药大学中药学医学学士，郑州大学有机化学理学博士，中国药科大学博士后。曾在河南省科学院化学研究所从事核磁共振、天然有机化学和有机合成研究。2001年9月入职中国医学科学院药物研究所，以承担和参与科研课题、发表研究论文、主编和参编专著、招收培养硕士和博士研究生以及申请专利为主线，从事科研和研究生教学工作。在科研工作中主要从事与特定药物作用靶点关联的黄连碱类化合物的药物化学研究，在教学工作中承担硕士生“波谱解析”课程的组织教师职责并讲授博士生“波谱解析”课程的1HNMR内容。多年来已深入开展了基于知识的黄连碱类化合物的药物化学研究，包括活性化合物合成及靶向合成、生物活性评价、与生物大分子的相互作用研究等，并以致力于创新药物研究体现相关的研究价值。

黄连碱类化合物是以苯环上连有不同取代基的异喹啉并[3,2-a]异喹啉之5,6-二氢-7-鎓离子季铵盐型或6,8-二氢-5H-叔胺型或6,8,13,13a-四氢-5H-叔胺型结构为核心特征的一大类化合物，其中，大多数5,6-二氢异喹啉并[3,2-a]异喹啉-7-鎓离子季铵盐型化合物的独特结构决定了其独特的生物活性。本研究组主要致力于与特定药物作用靶点关联的黄连碱类化合物的药物化学研究，涉及的主要研究内容包括基于知识和结构多样性的活性化合物靶向合成、生物活性评价和与生物大分子的相互作用研究；根据研究结果进一步深入开展以创新药物为导向的成药性评价。

1. Trifluoromethylation of dihydrocoptisines and the effect on structural stability and XBP1-activating activity. Xiang Li, Hai-Jing Zhang, Zhi-Hong Li, Liang-Qiu Wu*, An-Jun Deng*, Hai-Lin Qin*, Journal of. Asian Natural. Products Research, 2021, 17(7): 10.1080/10286020.2021.1935895.
2. Syntheses and Structure-Activity Relationships in Antibacterial Activity against Clostridium difficile and XBP1 Activation Property of 13-[(N-Alkylamino)methyl]-8-oxodihydrocoptisines. Jing Li, Hai-Jing Zhang, An-Jun Deng, Zhi-Hong Li, Ya-Ling Xing,* Lian-Qiu Wu,* and Hai-Lin Qin*. Chemistry  Biodiversity, 2020, 17(7): e2000265.
3. Syntheses and Structure–Activity Relationships in Growth Inhibition Activity against Human Cancer Cell Lines of 12 Substituted Berberine Derivatives. Molecules, Bo Wang, An-Jun Deng*, Zhi-Hong Li, Nan Wang and Hai-Lin Qin*, 2020, 25:1871.
4. Syntheses and structure-activity relationships on antibacterial and anti-ulcerative colitis properties of quaternary 13-substituted palmatines and 8-oxo-13-substituted dihydropalmatines. Li Song, Hai-Jing Zhang, An-Jun Deng, Jia Li, Xiang Li, Zhi-Hong Li, Zhi-Hui Zhang, Lian-Qiu Wu*, Sheng-Qi Wang*, Hai-Lin Qin*, Bioorganic & Medicinal Chemistry, 2018, 26(9):2586-2598.
5. Synthesis of quaternary 8-(1-acylethene-1-yl)-13-methylcoptisine chlorides and their selective growth inhibitory activity between human cancer cell lines and normal intestinal epithelial cell-6. Zhi-Hui Zhang, Yu Yan, An-Jun Deng, Hai-Jing Zhang, Zhi-Hong Li, Tian-Yi Yuan, Lian-Hua Fang, Lian-Qiu Wu, Guan-Hua Du, Hai-Lin Qin*, Chinese Chemical Letters, 2018, 29:131-135.
6. Development of an XBP1 agonist, HLJ2, as a potential therapeutic agent for ulcerative colitis. HaiJing Zhang, ZhiHui Zhang, GuangMing Song, XiaoNan Tang, HuaChen Song, AnJun Deng, WenJie Wang, LianQiu Wu, Hailin Qin. European journal of Pharmaceutical Sciences, 2017, 109: 56-64.
7. Colitis is effectively ameliorated by (±)-8-acetonyl-dihydrocoptisine via XBP1-NF-κB pathway. HaiJing Zhang, GuangMing Song, ZhiHui Zhang, HuaChen Song, XiaoNan Tang, AnJun Deng, WenJie Wang, LianQiu Wu*, and HaiLin Qin*, Frontiers in Pharmacology, 2017, 8: 619
8. Versatile methods for synthesizing organic acid salts of quaternary berberine-type alkaloids as anti-ulcerative colitis agents. Zhi-Hui Zhang, Jing Li, Hai-Jing Zhang, An-Jun Deng, Lian-Qiu Wu*, Zhi-Hong Li, Hong-Rui Song, Wen-Jie Wang, Hai-Lin Qin*. Journal of. Asian Natural. Products Research, 2016, 18, 576-586.
9. Synthesis and Structure-Activity Relationships of N-Dihydrocoptisine-8-ylidene Aromatic Amines and N-Dihydrocoptisine-8-ylidene Aliphatic Amides as Anti-ulcerative Colitis Agents Targeting XBP1. Meng Xie, Hai-Jing Zhang, An-Jun Deng, Lian-Qiu Wu*, Zhi-Hui Zhang, Zhi-Hong Li, Wen-Jie Wang, and Hai-Lin Qin*, Journal of Natural Products. 2016, 79, 775-783.
10. Synthesis and Structure-activity Relationships of Quaternary Coptisine Derivatives as Potential Anti-ulcerative Colitis Agents. Zhi-Hui Zhang, Hai-Jing Zhang, An-Jun Deng, Bo Wang, Zhi-Hong Li, Yang Liu, Lian-Qiu Wu*, Wen-Jie Wang, and Hai-Lin Qin*. Journal of Medicinal Chemistry. 2015, 58, 7557-7571.
11. New Synthetic Method of 8-Oxocoptisine Starting from Natural Quaternary Coptisine as anti-Ulcerative Colitis Agent. Zhi-Hui Zhang, Lian-Qiu Wu, An-Jun Deng, Jin-Qian Yu, Zhi-Hong Li, Hai-Jing Zhang, Weng-Jie Wang, Hai-Lin Qin, Journal of. Asian Natural. Products Research, 2014, 16(8), 841-846.
12. Syntheses and structure–activity relationships in cytotoxicities of 13-substituted quaternary coptisine derivatives. Zhi-Hui Zhang, An-Jun Deng, Lian-Qiu Wu, Lian-Hua Fang, Jin-Qian Yu, Zhi-Hong Li, Tian-Yi Yuan, Wen-Jie Wang, Guan-Hua Du, Hai-Lin Qin*, European Journal of Medicinal Chemistry, 2014, 86, 542-549.

1. 1H NMR Handbook of Natural Products, Volume 1, Alkaloids. Hailin Qin, Dequan Yu, et.al. DE GRUYTER, Chemistry Industry Press, 2021 (ISBN 978-3-11-062434-2).
2. 1H NMR Handbook of Natural Products, Volume 2: Saponins. Hailin Qin, Dequan Yu, et.al. DE GRUYTER, Chemistry Industry Press, 2021 (ISBN 978-3-11-063074-9).
3. 1H NMR Handbook of Natural Products, Volume 3: Flavonoids, Quinones, Phenylpropanoids, and Stilbenes. Hailin Qin, Dequan Yu, et.al. DE GRUYTER, Chemistry Industry Press, 2021 (ISBN 978-3-11- 063077-0).
4. 1H NMR Handbook of Natural Products, Volume 4: Monoterpenoids and Sesquiterpenoids. Hailin Qin, Dequan Yu, et.al. DE GRUYTER, Chemistry Industry Press, 2021 (ISBN 978-3-11- 063078-7).
5. 核磁共振二维谱.赵天增，秦海林，张海燕，屈凌波编著，化学工业出版社，2018.1(ISBN 978-7-122- 30387-5)
6. 分析化学手册第三版“氢-1核磁共振波谱分析”. 秦海林，于德泉主编, 化学工业出版社，2016.1(ISBN 978-7-122- 27858-6)

1. 二氢巴马汀抗UC的用途. 秦海林，王文杰，张志辉，吴练秋，邓安珺，于金倩，李志宏，授权公告日：2019年5月31日.专利号：ZL201610806973.3.