科研队伍

研究员,硕士生导师。中国中药协会微循环用药专业委员会常务委员、国家禁毒委员会非药用类麻醉药品和精神药品专家委员会委员、北京药理学会心脑血管药理专业委员会委员。在国内外重要刊物发表论文70余篇。参与编写专著三部。主持承担各种国家省部级科研项目19项。包括863计划国家支撑项目、科技部“重大新药创制”科技重大专项“十三五” 计划项目、北京自然科学基金面上项目、中国医学科学院医学与健康科技创新工程专项等。

本实验室研究方向为核磁共振技术在药物研发中的应用研究。包括:
1. 多组学在创新药物的发现、评价和成药性等关键环节应用研究;
2. 核磁共振技术在药物研发中新技术及新方法研究;
3. 基于核磁技术的生物大分子与药物小分子相互作用研究。
在近几年时间里,在863、十三五和院创新工程等基金资助下,开展了模式动物、临床病人心脑血管多组学数据整合分析、药物代谢分析及靶标与新药候选化合物相互作用研究。旨在在精准刻画生命的分子特征和药物作用物质基础前提下,探索二者在生命体征中可能的相互作用与影响。

1. Gut microbiota combined with metabolites reveals unique features of acute myocardial infarction patients different from stable coronary artery disease. Chaoran Dong#, Yanan Yang#, Yinghong Wang#, Xiaomin Hu#, Qingchun Wang, Feng Gao, Shanshan Sun, Qifeng Liu, Lei Li, Jianxun Liu*, Yida Tang*, Shuyang Zhang*, Chongming Wu*, Haibo Zhu*. Journal of advanced research, 2023. 46 ,101–112.
2. Discovery of a series of selective and cell permeablebeta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR. Wei-Shuo Fang#*, De-yang Sun, Shuang Yang, Chen Cheng, Katrin Moschke, Tianqi Li, Shanshan Sun, Stefan F. Lichtenthaler, JianHuang , Yinghong Wang*. Bioorganic Chemistry 2019, 92, 103253.
3. Application of Band-Selective HSQC NMR in Species Discrimination and Adulteration Identification of Panax Linn. Congcong Guo#, Jiyang Dong#, Lingli Deng, Kiankai Cheng, Yue Xu, Haowen Zhu, Anjun Deng, Xia Zhou, Hailin Qin*, Yinghong Wang*. Molecules 2023, 28, no. 11: 4332.
4. The application of combined 1H NMR-based metabolomics and transcriptomics techniques to explore phenolic acids biosynthesis in Salvia miltiorrhiza Bunge. Xia Liu, MengxiaJin, Min Zhang, Tianqi Li, Shanshan Sun, Jinyue Zhang, Jungui Dai, Yinghong Wang*. Journal of Pharmaceutical and Biomedical Analysis.2019, 172, 126–138.
5. Comprehensive characterization of the in vitro and in vivo metabolites of IMM-H007 in rats using HPLC-DAD, UPLC-MS/MS and off-Line NMR. MengxiaJin, Na Guo, Tianqi Li, Xia Liu, Shanshan Sun, XiangjuJin, Haibo Zhu, Hailin Qin, Yinghong Wang*. Journal of Chromatography B.2018, 1096, 187–200.
6. Beneficial metabolic effects of 2’, 3’, 5’-tri-acetyl-N6-(3-hydroxylaniline) adenosine in multiple biological matrices and intestinal flora of hyperlipidemic hamsters. Tianqi Li, Shanshan Sun, Jinyue Zhang, Kai Qu, Liu Yang, Changlu Ma, XiangjuJin, Haibo Zhu*, Yinghong Wang*. Journal of Proteome Research. 2018, Aug 3;17(8):2870-2879.
7. The Application of Quantitative 1H-NMR for the Determination of Orlistat in Tablets. Shanshan Sun, MengxiaJin, Xia Zhou, Jinghua Ni, XiangjuJin, Hongyue Liu and Yinghong Wang *. Molecules. 2017, 22, 1517.
8. Silibinin Capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidation. Chun-Xue Cui, Jing-Na Deng, Li Yan, Yu-Ying Liu, Jing-Yu Fan, Hong-Na Mu, Hao-Yu Sun, Ying-Hong Wang*, Jing-Yan Han*.Journal of Ethnopharmacology. 2017, 208 ,24–35.
9. Quantitative metabolomic profiling of plasma, urine, and liver extracts by 1H NMR spectroscopy characterizes different stages of atherosclerosis in hamsters. Wei Guo, Chunying Jiang, Liu Yang, Tianqi Li, Xia Liu, MengxiaJin, Kai Qu, Huili Chen, XiangjuJin, Hongyue Liu, Haibo Zhu*, Yinghong Wang*. Journal of Proteome Research. 2016, 15(10): 3500-3510.
10. The application of HPLC and microprobe NMR spectroscopy in the identification of metabolites in complex biological matrices. Zhaoxia Miao, MengxiaJin, Xia Liu, Wei Guo, XiangjuJin, Hongyue Liu, Yinghong Wang*. Analytical and Bioanalytical Chemistry. 2015, 407(12), 3405-341.
11. Structure elucidation of the metabolites of 2', 3', 5'-tri-O-acetyl-N6-(3-hydroxyphenyl) adenosine in rat urine by HPLC-DAD, ESI-MS and off-line microprobe NMR. Wei Guo, MengxiaJin, Zhaoxia Miao, Xia Liu, Xiangju Jing, Hongyue Liu, Yinghong Wang*. PLoS ONE. 2015, 10(6), e0127583.
12. Quantitative 1H-NMR method for the determination of Tadalafil in bulk drugs and its tablets. Qingyun Yang, Hui Qiu, Wei Guo, Dongmei Wang, Xingning Zhou, Dan Xue, Jinlan Zhang, Song Wu*, Yinghong Wang*. Molecules. 2015.
13. A 1H NMR-Based metabonomic investigation of time-related metabolic trajectories of the plasma, urine and liver extracts of hyperlipidemic hamsters. Chunying Jiang, Kangmin Yang, Liu Yang, Zhaoxia Miao, Yinghong Wang*, Haibo Zhu*. PLoS ONE. 2013, 8(6), e66786.
14. A systematic, integrated study on the neuroprotective effects of hydroxysafflor yellow A based on 1H NMR-based metabonomics and the NF-κB pathway. Yuanyan Liu, Zeqin Lian, Yinghong Wang*, Shishan Yu*, Haibo Zhu. Evidence-Based Complementary and Alternative Medicine (eCAM). Volume 2013, Article ID 147362, 14 pages http://dx.doi.org/10.1155/2013/147362.
15. Beneficial metabolic effects of 2′, 3′, 5′-tri-acetyl-N6-(3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters. Yang Sun, Zeqin Lian, Chunying Jiang, Yinghong Wang*, Haibo Zhu*. PLoS ONE. 2012, 7( 3 ).e32115.
16. On-line identification of 4-isovalerylspiramycin I in the genetic engineered strain of S. spiramyceticus F21 by liquid chromatography with electrospray ionization tandem mass spectrometry, ultraviolet absorbance detection and nuclear magnetic resonance spectrometry. Jingyan Li, Chunyan Ma, Hongyuan Wang, Yinghong Wang, Linzhuan Wu, Yiguang Wang*. Journal of Chromatography A. 2010, 1217, 1419–1424.
17. Rapid structural determination of new trace cassaine-type diterpenoid amides in fractions from erythrophleumfordii by liquid chromatography-dioe-array detection/electrospray ionization tandem mass spectrometry and liquid chromatography/nuclear magnetic resonance. Jing Qu#, Yinghong Wang#, Jianbei Li, Yuan Li, Yunbao Liu, Shishan Yu*. Rapid Communications in Mass Spectrometry. 2007, 21:2109-2119.
18. 1H-NMR signal assignment and secondary structure analysis of martentoxin. YingHong Wang, ZhengYu Cao, WenYi He, Xing Liu, HongYue Liu, DeQuan Yu*. Journal of Asian Natural Products Research. 2006, 8(6) 511-518.
19. Two novel glycosidic triterpene alkaloids from the stem barks of machilusyaoshansis. Mingtao Liu, Sheng Lin, Yinghong Wang, Wenyi He, Shuai Li, Yongchun Yang, Sujuan Wang, Jiangong Shi*. Organic Letters. 2007, 9,1,129-132.
# 并列第一作者,* 通讯作者

1. 新精神活性物质办案实用手册,马岩,法律出版社,2019年
2. 天然产物研究方法和技术,再帕尔·阿不力孜,化学工业出版社,2010年
3. 高等仪器分析实验与技术,凌笑梅,北京大学医学出版社,2006年。