1. 工作经历
2015.09-2017.02 香港城市大学,高级研究助理
2017.06-2019.05 中国医学科学院药物研究所,博士后
2019.06-2022.09 中国医学科学院药物研究所,助理研究员
2022.09至今 中国医学科学院药物研究所,副研究员
2. 教育背景
2005.09-2009.07 中国药科大学,生物工程,学士
2009.09-2015.07 北京大学药学院,药物化学,博士
3. 在研项目
(1)PI3K/HDAC双重抑制剂的设计、合成和活性评价
(2)光控激酶抑制剂前药的设计、合成和活性评价
(3)细胞钙信号调节剂的设计、合成和活性评价
基于前期研究成果,通过合理药物设计的方法,开展PI3K/HDAC双重靶向的小分子抑制剂的设计、合成与抗肿瘤活性研究;结合光激活前药的概念,开展新型光控激酶抑制剂前药的设计与合成,并探索其在体内外模型中的抗肿瘤活性;针对细胞内钙信号通路,开发小分子钙信号调节剂,并深入研究其生理活性与作用机制。
1. Identification of a small chemical as a lysosomal calcium mobilizer and characterization of its ability to inhibit autophagy and viral infection. Zhang Kehui, Huang Lihong, Cai Yang, Zhong Yi, Chen Nanjun, Gao Fei, Zhang Liang, Li Qi, Liu Zhenming, Zhang Rongxin, Zhang Liangren, Yue Jianbo*. FEBS J. 2023.
2. Bioevaluation of a dual PI3K/HDAC inhibitor for the treatment of diffuse large B-cell lymphoma. Zhang Kehui, Huang Lei, Lai Fangfang, Lin Songwen, Tian Hua, Wu Deyu, Chen Xiaoguang*, Xu Heng*. Bioorganic & Medicinal Chemistry Letters, 2022, 71, 128825.
3. Design, synthesis, and biological evaluation of a novel photocaged PI3K inhibitor toward precise cancer treatment. Zhang Kehui, Ji Ming, Lin Songwen, Peng Shouguo, Zhang Zhihui, Zhang Mingyi, Zhang Jingbo, Zhang Yan, Wu Deyu, Tian Hua, Chen Xiaoguang*, Xu Heng*. Journal of Medicinal Chemistry, 2021, 64, 7331-7340.(补充封面论文)
4. Design, synthesis, and biological evaluation of 4-methyl quinazoline derivatives as anticancer agents simultaneously targeting phosphoinositide 3-kinases and histone deacetylases. Zhang Kehui, Lai Fangfang, Lin Songwen, Ji Ming, Zhang Jingbo, Zhang Yan, Jin Jing, Fu Rong, Wu Deyu, Tian Hua, Xue Nina, Sheng Li, Zou Xiaowen, Li Yan, Chen Xiaoguang*, Xu Heng*. Journal of Medicinal Chemistry, 2019, 62, 6992-7014.(封面论文)
5. Identifying glyceraldehyde 3-phosphate dehydrogenase as a cyclic adenosine diphosphoribose binding protein by photoaffinity protein–ligand labeling approach. Zhang Kehui, Sun Wei, Huang Lihong, Zhu Kaiyuan, Pei Fen, Zhu Longchao, Wang Qian, Lu Yingying, Zhang Hongmin, Jin Hongwei, Zhang Li-He*, Zhang Liangren*, Yue Jianbo*. Journal of the American Chemical Society, 2017, 139, 156-170.
1. 多取代的喹唑啉类衍生物及其制备方法、药物组合物和用途。许恒,陈晓光,张可辉,来芳芳,林松文,伏蓉,金晶,季鸣。中国专利号:ZL201910161874.8;授权日:2022-07-19。