科研队伍

朱平,男, 博士生导师。室主任、本所国重室副主任、中国菌物学会副理事长、《药学学报》和《菌物学报》编委等。在Nature Communications、Green Chemistry (封底图片)、Molecular & Cellular Proteomics (封面图片)、Acta Pharmaceutica Sinica B、Fungal Diversity等国际知名期刊发表多篇SCI论文。累计授权8项中国专利和10项国际专利。参编著作6部。获得2011年中国药学会科学技术三等奖和“2020年度北京协和医学院优秀教师”称号。培养的博士研究生中分别有1名荣获“2018年度北京协和医学院优秀博士学位论文”和1名荣获“2019年度北京市普通高等学校优秀毕业生”称号。合作发现3ʹ-脱氧腺苷的降血脂功能及其作为AMPK激动剂的作用机制,本所科技人员以此为先导物,已研制出新型降血脂药物;麦角生物碱的研究为相关企业提供了技术支撑。

微生物工程与天然药物合成生物学。目前主要开展:1) 药用天然产物生物合成基因的挖掘与酶的表征、生物合成途径解析及微生物系统中的途径重构研究; 2) 药用真菌、动植物内共生菌活性代谢产物的发现、生产与创新药物研究。

1. Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10- deacetylbaccatin III to baccatin III. Hao Wang, Bo-Yong Zhang, Ting Gong, Tian-Jiao Chen, Jing-Jing Chen, Jin-Ling Yang, Ping Zhu*. Acta Pharmaceutica Sinica B, 2021, https://doi.org/10.1016/j.apsb.2021.03.029 (IF=11.413)
2. De novo transcriptome sequencing of Rhododendron molle and identification of genes involved in the biosynthesis of secondary metabolites. Guo-Lin Zhou, Ping Zhu*. BMC Plant Biology, 2020, 20(1), 414. (IF=4.215)
3. Structures of β-glycosidase LXYL-P1-2 reveals the product binding state of GH3 family and a specific pocket for Taxol recognition. Lin Yang#, Tian-Jiao Chen#, Fen Wang Li Li, Wen-Bo Yu, Yi-Kang Si, Jing-Jing Chen, Wan-Cang Liu, Ping Zhu*, Weimin Gong *. Communications Biology, 2020, 3(1), 22. (IF=6.268)
4. High-level soluble expression of human Cu, Zn superoxide dismutase with high activity in Escherichia coli. Jin-Ling Yang, Xing-Lun Li, Feng-Lin Jiang, Ting Gong, Jing-Jing Chen, Tian-Jiao Chen, Ping Zhu*. World Journal of Microbiology and Biotechmology, 2020, 36, 106.(IF=2.477)
5. Construction and optimization of microbial cell factories for the sustainable production of bioactive dammarenediol-II glucosides. Zong-Feng Hu#, An-Di Gu#, Lan Liang, Yan Li, Ting Gong, Jing-Jing Chen, Tian-Jiao Chen, Jin-Ling Yang*, Ping Zhu*. Green Chemistry, 2019, 219(12): 3286-3299. (back cover image of the present Issue) (IF=9.480)
6. Fed-batch high-cell-density fermentation strategies for Pichia pastoris growth and production. Liu WC, Inwood S, Gong T, Sharma A, Yu LY*, Ping Zhu*. Critical Reviews in Biotechnology, 2019, 39(2): 258-271. (IF=8.108)
7. Combinatorial mutation on the β-glycosidase specific to 7-β-xylosyltaxanes and increasing the mutated enzyme production by engineering the recombinant yeast. Jing-Jing Chen, Xiao Liang, Fen Wang, Yan-Hua Wen, Tian-Jiao Chen, Wan-Cang Liu, Ting Gong, Jin-Ling Yang, Ping Zhu*. Acta Pharmaceutica Sinica B, 2019, 9(3):626-638. (IF=7.097)
8. Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites. Yun-Ming Qiao, Rui-Lin Yu, Ping Zhu*. RSC Advances, 2019, 9, 35124–35134. (IF=3.119)
9. Epigenetic modification enhances ergot alkaloid production of Claviceps purpurea. Jing-Jing Chen, Meng-Yao Han, Ting Gong, Yun-Ming Qiao, Jin-Ling Yang, Ping Zhu*. Biotechnology Letters, 2019, 41,1439–1449. (IF=1.977)
10. Site-Directed Mutagenesis of bata-Glycoside Hydrolase from Lentinula edodes. Jing-Jing Chen, Xiao Liang, Tian-Jiao Chen, Jin-Ling Yang and Ping Zhu*. Molecules, 2019, 24, 59 (IF=3.267)
11. Tetrocarcin Q, a new spirotetronate with a unique glycosyl group from a marine-derived actinomycete Micromonospora carbonacea LS276. Ting Gong, Xin Zhen, Xing-Lun Li, Jing-Jing Chen, Tian-Jiao Chen, Jin-Ling Yang, Ping Zhu*. Marine Drugs, 2018, 16, 74. (IF=4.379)
12. Chrysoxanthones A–C, three new xanthone–chromanone heterdimers from sponge-associated Penicillium chrysogenum HLS111 treated with histone deacetylase inhibitor. Xin Zhen#, Ting Gong#, Yan-Hua Wen, Dao-Jiang Yan, Jing-Jing Chen, Ping Zhu*. Marine Drugs, 2018, 16, 357. (IF=4.379)
13. Improving 10-deacetylbaccatin III-10-β-Oacetyltransferase catalytic fitness for Taxol production. Bing-Juan Li, Hao Wang, Ting Gong, Jing-Jing Chen, Tian-Jiao Chen, Jin-Ling Yang, Ping Zhu*. Nature Communication, 2017, 8, 15544. (IF=12.353)
14. Cloning and characterization of the glycoside hydrolases that remove xylosyl group from 7-β-xylosyl-10-deacetyltaxol and its analogues. Hai-Li Cheng, Rui-Yu Zhao, Tian-Jiao Chen, Wen-Bo Yu, Fen Wang, Ke-Di Cheng, Ping Zhu*. Molecular & Cellular Proteomics, 2013, 12(8):2236-2248. (Cover Image and Highlight from this Issue) (IF=7.254)
15. Phylogenetic diversity of culturable fungi associated with two marine sponges: Haliclona simulans and Gelliodes carnosa, collected from the Hainan Island coastal waters of the South China Sea. Wen-Chao Liu, Chang-Qing Li, Ping Zhu*. Jin-Ling Yang, Ke-Di Cheng. Fungal Diversity, 2010, 42:1-15. (IF=5.074)

1. 2020. 北京协和医学院优秀教师奖. 朱平. 北京协和医学院. 2. 2011. 稀有天然药物生物合成与合成生物学研究. 程克棣,朱平,孔建强,王伟,涂珺,刘涛,袁玮,刘颖,张利平. 中国药学会科学技术奖. 三等奖.